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Safety and feasibility of in-hospital early chemotherapy initiation after surgery in patients with stage II–IV colon cancer

Although it is recommended to initiate postoperative chemotherapy for colon cancer within 8 weeks after surgery, the feasibility and impact of initiating chemotherapy before discharge after surgical resection has not been investigated. Patients with stage II–IV colon cancer who received postoperativ...

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Autores principales: Kang, Jeonghyun, Chong, Su-Weon, Park, Eun Jung, Baik, Seung Hyuk, Lee, Kang Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504305/
https://www.ncbi.nlm.nih.gov/pubmed/31045781
http://dx.doi.org/10.1097/MD.0000000000015371
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author Kang, Jeonghyun
Chong, Su-Weon
Park, Eun Jung
Baik, Seung Hyuk
Lee, Kang Young
author_facet Kang, Jeonghyun
Chong, Su-Weon
Park, Eun Jung
Baik, Seung Hyuk
Lee, Kang Young
author_sort Kang, Jeonghyun
collection PubMed
description Although it is recommended to initiate postoperative chemotherapy for colon cancer within 8 weeks after surgery, the feasibility and impact of initiating chemotherapy before discharge after surgical resection has not been investigated. Patients with stage II–IV colon cancer who received postoperative chemotherapy were dichotomized into early (chemotherapy initiation before discharge) and control (chemotherapy initiation after discharge) groups. A multivariable logistic regression model was used to determine factors associated with delayed chemotherapy, defined as more than 6 or 8 weeks after surgery. From January 2004 to December 2012, of 729 patients with stage II–IV colon adenocarcinoma, 555 patients (76.1%) underwent postoperative chemotherapy. Of them, 181 (32.6%) patients were included in the early group. Time to initiation of chemotherapy was significantly shorter in the early group than in the control group (14.9 days vs 31.5 days, P < . 001). Multivariate analysis revealed that tumor stage and chemotherapy initiation strategy (odds ratio 8.4; 95% confidence interval, 1–66, P = .041) were independent predictors of delayed initiation of chemotherapy at more than 8 weeks. There was no difference in the completion rate of planned chemotherapy cycles between the 2 groups (P > .05). The strategy of initiating chemotherapy before discharge after surgery is safe and feasible and might reduce the potential delay in chemotherapy initiation in patients with colon cancer.
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spelling pubmed-65043052019-05-29 Safety and feasibility of in-hospital early chemotherapy initiation after surgery in patients with stage II–IV colon cancer Kang, Jeonghyun Chong, Su-Weon Park, Eun Jung Baik, Seung Hyuk Lee, Kang Young Medicine (Baltimore) Research Article Although it is recommended to initiate postoperative chemotherapy for colon cancer within 8 weeks after surgery, the feasibility and impact of initiating chemotherapy before discharge after surgical resection has not been investigated. Patients with stage II–IV colon cancer who received postoperative chemotherapy were dichotomized into early (chemotherapy initiation before discharge) and control (chemotherapy initiation after discharge) groups. A multivariable logistic regression model was used to determine factors associated with delayed chemotherapy, defined as more than 6 or 8 weeks after surgery. From January 2004 to December 2012, of 729 patients with stage II–IV colon adenocarcinoma, 555 patients (76.1%) underwent postoperative chemotherapy. Of them, 181 (32.6%) patients were included in the early group. Time to initiation of chemotherapy was significantly shorter in the early group than in the control group (14.9 days vs 31.5 days, P < . 001). Multivariate analysis revealed that tumor stage and chemotherapy initiation strategy (odds ratio 8.4; 95% confidence interval, 1–66, P = .041) were independent predictors of delayed initiation of chemotherapy at more than 8 weeks. There was no difference in the completion rate of planned chemotherapy cycles between the 2 groups (P > .05). The strategy of initiating chemotherapy before discharge after surgery is safe and feasible and might reduce the potential delay in chemotherapy initiation in patients with colon cancer. Wolters Kluwer Health 2019-05-03 /pmc/articles/PMC6504305/ /pubmed/31045781 http://dx.doi.org/10.1097/MD.0000000000015371 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle Research Article
Kang, Jeonghyun
Chong, Su-Weon
Park, Eun Jung
Baik, Seung Hyuk
Lee, Kang Young
Safety and feasibility of in-hospital early chemotherapy initiation after surgery in patients with stage II–IV colon cancer
title Safety and feasibility of in-hospital early chemotherapy initiation after surgery in patients with stage II–IV colon cancer
title_full Safety and feasibility of in-hospital early chemotherapy initiation after surgery in patients with stage II–IV colon cancer
title_fullStr Safety and feasibility of in-hospital early chemotherapy initiation after surgery in patients with stage II–IV colon cancer
title_full_unstemmed Safety and feasibility of in-hospital early chemotherapy initiation after surgery in patients with stage II–IV colon cancer
title_short Safety and feasibility of in-hospital early chemotherapy initiation after surgery in patients with stage II–IV colon cancer
title_sort safety and feasibility of in-hospital early chemotherapy initiation after surgery in patients with stage ii–iv colon cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504305/
https://www.ncbi.nlm.nih.gov/pubmed/31045781
http://dx.doi.org/10.1097/MD.0000000000015371
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