Cargando…

Pleural effusion as a substitute for tumor tissue in detecting EGFR/ALK mutations in non-small cell lung cancer: A systematic review and meta-analysis

BACKGROUND: Pleural effusion (PE) has been reported useful in many studies for testing epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) with variable results. This systematic review and meta-analysis was performed to elucidate whether PE could be used as a surr...

Descripción completa

Detalles Bibliográficos
Autores principales: Pang, Caishuang, Ma, Huiwen, Qin, Jiangyue, Wang, Sixiong, Wan, Chun, Yang, Ting, Shen, Yongchun, Wang, Donglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504331/
https://www.ncbi.nlm.nih.gov/pubmed/31045816
http://dx.doi.org/10.1097/MD.0000000000015450
_version_ 1783416554379018240
author Pang, Caishuang
Ma, Huiwen
Qin, Jiangyue
Wang, Sixiong
Wan, Chun
Yang, Ting
Shen, Yongchun
Wang, Donglin
author_facet Pang, Caishuang
Ma, Huiwen
Qin, Jiangyue
Wang, Sixiong
Wan, Chun
Yang, Ting
Shen, Yongchun
Wang, Donglin
author_sort Pang, Caishuang
collection PubMed
description BACKGROUND: Pleural effusion (PE) has been reported useful in many studies for testing epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) with variable results. This systematic review and meta-analysis was performed to elucidate whether PE could be used as a surrogate for tumor tissue to detect EGFR mutations. METHODS: We extracted 2 × 2 diagnostic table from each included study and calculated data on specificity, sensitivity, negative likelihood ratio (NLR), positive likelihood ratio (PLR) ,and diagnostic odds ratio (DOR). We used the area under curve (AUC) and summary receiver operating characteristic curve (SROC) to summarize the overall diagnostic performance and assessed publication bias by Deeks’ funnel plot. RESULTS: Our meta-analysis included 15 eligible publications. The following summary estimates for diagnostic parameters of the EGFR mutations detection in PE were made: sensitivity, 0.86 (95%CI 0.83–0.89); specificity, 0.93 (95%CI 0.91–0.95); PLR, 8.53 (95%CI 5,94–12.25); NLR, 0.18 (95%CI 0.13–0.25); DOR, 63.40 (95%CI 38.83–103.51); and AUC, 0.94. Funnel plot indicated publication bias insignificant. CONCLUSIONS: The meta-analysis suggests that EGFR mutation detecting in PE, especially supernatants, is a promising surrogate for tumor tissue in EGFR mutations testing of patients with NSCLC.
format Online
Article
Text
id pubmed-6504331
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Wolters Kluwer Health
record_format MEDLINE/PubMed
spelling pubmed-65043312019-05-29 Pleural effusion as a substitute for tumor tissue in detecting EGFR/ALK mutations in non-small cell lung cancer: A systematic review and meta-analysis Pang, Caishuang Ma, Huiwen Qin, Jiangyue Wang, Sixiong Wan, Chun Yang, Ting Shen, Yongchun Wang, Donglin Medicine (Baltimore) Research Article BACKGROUND: Pleural effusion (PE) has been reported useful in many studies for testing epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) with variable results. This systematic review and meta-analysis was performed to elucidate whether PE could be used as a surrogate for tumor tissue to detect EGFR mutations. METHODS: We extracted 2 × 2 diagnostic table from each included study and calculated data on specificity, sensitivity, negative likelihood ratio (NLR), positive likelihood ratio (PLR) ,and diagnostic odds ratio (DOR). We used the area under curve (AUC) and summary receiver operating characteristic curve (SROC) to summarize the overall diagnostic performance and assessed publication bias by Deeks’ funnel plot. RESULTS: Our meta-analysis included 15 eligible publications. The following summary estimates for diagnostic parameters of the EGFR mutations detection in PE were made: sensitivity, 0.86 (95%CI 0.83–0.89); specificity, 0.93 (95%CI 0.91–0.95); PLR, 8.53 (95%CI 5,94–12.25); NLR, 0.18 (95%CI 0.13–0.25); DOR, 63.40 (95%CI 38.83–103.51); and AUC, 0.94. Funnel plot indicated publication bias insignificant. CONCLUSIONS: The meta-analysis suggests that EGFR mutation detecting in PE, especially supernatants, is a promising surrogate for tumor tissue in EGFR mutations testing of patients with NSCLC. Wolters Kluwer Health 2019-05-03 /pmc/articles/PMC6504331/ /pubmed/31045816 http://dx.doi.org/10.1097/MD.0000000000015450 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle Research Article
Pang, Caishuang
Ma, Huiwen
Qin, Jiangyue
Wang, Sixiong
Wan, Chun
Yang, Ting
Shen, Yongchun
Wang, Donglin
Pleural effusion as a substitute for tumor tissue in detecting EGFR/ALK mutations in non-small cell lung cancer: A systematic review and meta-analysis
title Pleural effusion as a substitute for tumor tissue in detecting EGFR/ALK mutations in non-small cell lung cancer: A systematic review and meta-analysis
title_full Pleural effusion as a substitute for tumor tissue in detecting EGFR/ALK mutations in non-small cell lung cancer: A systematic review and meta-analysis
title_fullStr Pleural effusion as a substitute for tumor tissue in detecting EGFR/ALK mutations in non-small cell lung cancer: A systematic review and meta-analysis
title_full_unstemmed Pleural effusion as a substitute for tumor tissue in detecting EGFR/ALK mutations in non-small cell lung cancer: A systematic review and meta-analysis
title_short Pleural effusion as a substitute for tumor tissue in detecting EGFR/ALK mutations in non-small cell lung cancer: A systematic review and meta-analysis
title_sort pleural effusion as a substitute for tumor tissue in detecting egfr/alk mutations in non-small cell lung cancer: a systematic review and meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504331/
https://www.ncbi.nlm.nih.gov/pubmed/31045816
http://dx.doi.org/10.1097/MD.0000000000015450
work_keys_str_mv AT pangcaishuang pleuraleffusionasasubstitutefortumortissueindetectingegfralkmutationsinnonsmallcelllungcancerasystematicreviewandmetaanalysis
AT mahuiwen pleuraleffusionasasubstitutefortumortissueindetectingegfralkmutationsinnonsmallcelllungcancerasystematicreviewandmetaanalysis
AT qinjiangyue pleuraleffusionasasubstitutefortumortissueindetectingegfralkmutationsinnonsmallcelllungcancerasystematicreviewandmetaanalysis
AT wangsixiong pleuraleffusionasasubstitutefortumortissueindetectingegfralkmutationsinnonsmallcelllungcancerasystematicreviewandmetaanalysis
AT wanchun pleuraleffusionasasubstitutefortumortissueindetectingegfralkmutationsinnonsmallcelllungcancerasystematicreviewandmetaanalysis
AT yangting pleuraleffusionasasubstitutefortumortissueindetectingegfralkmutationsinnonsmallcelllungcancerasystematicreviewandmetaanalysis
AT shenyongchun pleuraleffusionasasubstitutefortumortissueindetectingegfralkmutationsinnonsmallcelllungcancerasystematicreviewandmetaanalysis
AT wangdonglin pleuraleffusionasasubstitutefortumortissueindetectingegfralkmutationsinnonsmallcelllungcancerasystematicreviewandmetaanalysis