Cargando…
Pleural effusion as a substitute for tumor tissue in detecting EGFR/ALK mutations in non-small cell lung cancer: A systematic review and meta-analysis
BACKGROUND: Pleural effusion (PE) has been reported useful in many studies for testing epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) with variable results. This systematic review and meta-analysis was performed to elucidate whether PE could be used as a surr...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504331/ https://www.ncbi.nlm.nih.gov/pubmed/31045816 http://dx.doi.org/10.1097/MD.0000000000015450 |
_version_ | 1783416554379018240 |
---|---|
author | Pang, Caishuang Ma, Huiwen Qin, Jiangyue Wang, Sixiong Wan, Chun Yang, Ting Shen, Yongchun Wang, Donglin |
author_facet | Pang, Caishuang Ma, Huiwen Qin, Jiangyue Wang, Sixiong Wan, Chun Yang, Ting Shen, Yongchun Wang, Donglin |
author_sort | Pang, Caishuang |
collection | PubMed |
description | BACKGROUND: Pleural effusion (PE) has been reported useful in many studies for testing epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) with variable results. This systematic review and meta-analysis was performed to elucidate whether PE could be used as a surrogate for tumor tissue to detect EGFR mutations. METHODS: We extracted 2 × 2 diagnostic table from each included study and calculated data on specificity, sensitivity, negative likelihood ratio (NLR), positive likelihood ratio (PLR) ,and diagnostic odds ratio (DOR). We used the area under curve (AUC) and summary receiver operating characteristic curve (SROC) to summarize the overall diagnostic performance and assessed publication bias by Deeks’ funnel plot. RESULTS: Our meta-analysis included 15 eligible publications. The following summary estimates for diagnostic parameters of the EGFR mutations detection in PE were made: sensitivity, 0.86 (95%CI 0.83–0.89); specificity, 0.93 (95%CI 0.91–0.95); PLR, 8.53 (95%CI 5,94–12.25); NLR, 0.18 (95%CI 0.13–0.25); DOR, 63.40 (95%CI 38.83–103.51); and AUC, 0.94. Funnel plot indicated publication bias insignificant. CONCLUSIONS: The meta-analysis suggests that EGFR mutation detecting in PE, especially supernatants, is a promising surrogate for tumor tissue in EGFR mutations testing of patients with NSCLC. |
format | Online Article Text |
id | pubmed-6504331 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-65043312019-05-29 Pleural effusion as a substitute for tumor tissue in detecting EGFR/ALK mutations in non-small cell lung cancer: A systematic review and meta-analysis Pang, Caishuang Ma, Huiwen Qin, Jiangyue Wang, Sixiong Wan, Chun Yang, Ting Shen, Yongchun Wang, Donglin Medicine (Baltimore) Research Article BACKGROUND: Pleural effusion (PE) has been reported useful in many studies for testing epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) with variable results. This systematic review and meta-analysis was performed to elucidate whether PE could be used as a surrogate for tumor tissue to detect EGFR mutations. METHODS: We extracted 2 × 2 diagnostic table from each included study and calculated data on specificity, sensitivity, negative likelihood ratio (NLR), positive likelihood ratio (PLR) ,and diagnostic odds ratio (DOR). We used the area under curve (AUC) and summary receiver operating characteristic curve (SROC) to summarize the overall diagnostic performance and assessed publication bias by Deeks’ funnel plot. RESULTS: Our meta-analysis included 15 eligible publications. The following summary estimates for diagnostic parameters of the EGFR mutations detection in PE were made: sensitivity, 0.86 (95%CI 0.83–0.89); specificity, 0.93 (95%CI 0.91–0.95); PLR, 8.53 (95%CI 5,94–12.25); NLR, 0.18 (95%CI 0.13–0.25); DOR, 63.40 (95%CI 38.83–103.51); and AUC, 0.94. Funnel plot indicated publication bias insignificant. CONCLUSIONS: The meta-analysis suggests that EGFR mutation detecting in PE, especially supernatants, is a promising surrogate for tumor tissue in EGFR mutations testing of patients with NSCLC. Wolters Kluwer Health 2019-05-03 /pmc/articles/PMC6504331/ /pubmed/31045816 http://dx.doi.org/10.1097/MD.0000000000015450 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | Research Article Pang, Caishuang Ma, Huiwen Qin, Jiangyue Wang, Sixiong Wan, Chun Yang, Ting Shen, Yongchun Wang, Donglin Pleural effusion as a substitute for tumor tissue in detecting EGFR/ALK mutations in non-small cell lung cancer: A systematic review and meta-analysis |
title | Pleural effusion as a substitute for tumor tissue in detecting EGFR/ALK mutations in non-small cell lung cancer: A systematic review and meta-analysis |
title_full | Pleural effusion as a substitute for tumor tissue in detecting EGFR/ALK mutations in non-small cell lung cancer: A systematic review and meta-analysis |
title_fullStr | Pleural effusion as a substitute for tumor tissue in detecting EGFR/ALK mutations in non-small cell lung cancer: A systematic review and meta-analysis |
title_full_unstemmed | Pleural effusion as a substitute for tumor tissue in detecting EGFR/ALK mutations in non-small cell lung cancer: A systematic review and meta-analysis |
title_short | Pleural effusion as a substitute for tumor tissue in detecting EGFR/ALK mutations in non-small cell lung cancer: A systematic review and meta-analysis |
title_sort | pleural effusion as a substitute for tumor tissue in detecting egfr/alk mutations in non-small cell lung cancer: a systematic review and meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504331/ https://www.ncbi.nlm.nih.gov/pubmed/31045816 http://dx.doi.org/10.1097/MD.0000000000015450 |
work_keys_str_mv | AT pangcaishuang pleuraleffusionasasubstitutefortumortissueindetectingegfralkmutationsinnonsmallcelllungcancerasystematicreviewandmetaanalysis AT mahuiwen pleuraleffusionasasubstitutefortumortissueindetectingegfralkmutationsinnonsmallcelllungcancerasystematicreviewandmetaanalysis AT qinjiangyue pleuraleffusionasasubstitutefortumortissueindetectingegfralkmutationsinnonsmallcelllungcancerasystematicreviewandmetaanalysis AT wangsixiong pleuraleffusionasasubstitutefortumortissueindetectingegfralkmutationsinnonsmallcelllungcancerasystematicreviewandmetaanalysis AT wanchun pleuraleffusionasasubstitutefortumortissueindetectingegfralkmutationsinnonsmallcelllungcancerasystematicreviewandmetaanalysis AT yangting pleuraleffusionasasubstitutefortumortissueindetectingegfralkmutationsinnonsmallcelllungcancerasystematicreviewandmetaanalysis AT shenyongchun pleuraleffusionasasubstitutefortumortissueindetectingegfralkmutationsinnonsmallcelllungcancerasystematicreviewandmetaanalysis AT wangdonglin pleuraleffusionasasubstitutefortumortissueindetectingegfralkmutationsinnonsmallcelllungcancerasystematicreviewandmetaanalysis |