Clinical and pathological significance of Homo sapiens ceramide synthase 2 (CerS-2) in diverse human cancers

Homo sapiens ceramide synthase 2 (CerS-2) plays an important role in inhibiting invasion and metastasis of tumor cells and has been reported as a tumor metastasis suppressor gene in diverse cancers. Thus, low level of CerS-2 protein might suggest a bad prognosis and up-regulation of CerS-2 protein m...

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Detalles Bibliográficos
Autores principales: Zhang, Qian, Wang, Jin-yan, Yan, Wei, Wang, Dan-dan, Yang, Su-jin, Zhou, Si-ying, Zhong, Shan-liang, Tang, Jin-hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2019
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504659/
https://www.ncbi.nlm.nih.gov/pubmed/30988071
http://dx.doi.org/10.1042/BSR20181743
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author Zhang, Qian
Wang, Jin-yan
Yan, Wei
Wang, Dan-dan
Yang, Su-jin
Zhou, Si-ying
Zhong, Shan-liang
Tang, Jin-hai
author_facet Zhang, Qian
Wang, Jin-yan
Yan, Wei
Wang, Dan-dan
Yang, Su-jin
Zhou, Si-ying
Zhong, Shan-liang
Tang, Jin-hai
author_sort Zhang, Qian
collection PubMed
description Homo sapiens ceramide synthase 2 (CerS-2) plays an important role in inhibiting invasion and metastasis of tumor cells and has been reported as a tumor metastasis suppressor gene in diverse cancers. Thus, low level of CerS-2 protein might suggest a bad prognosis and up-regulation of CerS-2 protein might act as a promising therapeutic strategy for malignant tumors. In this review, we discussed the expression, as well as the clinical and pathological significance of CerS-2 in diverse human cancers. The pathological processes and molecular pathways regulated by CerS-2 were also summarized.
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spelling pubmed-65046592019-05-20 Clinical and pathological significance of Homo sapiens ceramide synthase 2 (CerS-2) in diverse human cancers Zhang, Qian Wang, Jin-yan Yan, Wei Wang, Dan-dan Yang, Su-jin Zhou, Si-ying Zhong, Shan-liang Tang, Jin-hai Biosci Rep Review Articles Homo sapiens ceramide synthase 2 (CerS-2) plays an important role in inhibiting invasion and metastasis of tumor cells and has been reported as a tumor metastasis suppressor gene in diverse cancers. Thus, low level of CerS-2 protein might suggest a bad prognosis and up-regulation of CerS-2 protein might act as a promising therapeutic strategy for malignant tumors. In this review, we discussed the expression, as well as the clinical and pathological significance of CerS-2 in diverse human cancers. The pathological processes and molecular pathways regulated by CerS-2 were also summarized. Portland Press Ltd. 2019-05-07 /pmc/articles/PMC6504659/ /pubmed/30988071 http://dx.doi.org/10.1042/BSR20181743 Text en © 2019 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Articles
Zhang, Qian
Wang, Jin-yan
Yan, Wei
Wang, Dan-dan
Yang, Su-jin
Zhou, Si-ying
Zhong, Shan-liang
Tang, Jin-hai
Clinical and pathological significance of Homo sapiens ceramide synthase 2 (CerS-2) in diverse human cancers
title Clinical and pathological significance of Homo sapiens ceramide synthase 2 (CerS-2) in diverse human cancers
title_full Clinical and pathological significance of Homo sapiens ceramide synthase 2 (CerS-2) in diverse human cancers
title_fullStr Clinical and pathological significance of Homo sapiens ceramide synthase 2 (CerS-2) in diverse human cancers
title_full_unstemmed Clinical and pathological significance of Homo sapiens ceramide synthase 2 (CerS-2) in diverse human cancers
title_short Clinical and pathological significance of Homo sapiens ceramide synthase 2 (CerS-2) in diverse human cancers
title_sort clinical and pathological significance of homo sapiens ceramide synthase 2 (cers-2) in diverse human cancers
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504659/
https://www.ncbi.nlm.nih.gov/pubmed/30988071
http://dx.doi.org/10.1042/BSR20181743
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