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Association between epicardial adipose tissue and adverse outcomes in coronary heart disease patients with percutaneous coronary intervention
We assessed the relationship between the volume of epicardial adipose tissue and long-term outcomes in patients with coronary heart disease (CHD) undergoing percutaneous coronary intervention (PCI). The patients with CHD were followed for at least 2 years after PCI. The epicardial adipose tissue vol...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504663/ https://www.ncbi.nlm.nih.gov/pubmed/30979830 http://dx.doi.org/10.1042/BSR20182278 |
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author | Lu, Changqing Jia, Helei Wang, Zhentao |
author_facet | Lu, Changqing Jia, Helei Wang, Zhentao |
author_sort | Lu, Changqing |
collection | PubMed |
description | We assessed the relationship between the volume of epicardial adipose tissue and long-term outcomes in patients with coronary heart disease (CHD) undergoing percutaneous coronary intervention (PCI). The patients with CHD were followed for at least 2 years after PCI. The epicardial adipose tissue volume (EATV) was measured using multi-slice computed tomography. Cox regression analysis was used to examine the relationship between EATV and clinical outcome. In this study, 500 patients were enrolled and followed up for a median of 25.2 months. The incidence of adverse cardiovascular events was 12.4%. No significant differences were observed in age, sex, proportion of patients with hypertension or diabetes, smoking, drinking, total cholesterol, triglyceride, high-density lipoprotein, or unstable angina pectoris among different EATV quartiles (P>0.05). The EATV was associated with body mass index (P<0.0001), low-density lipoprotein level (P=0.039), high-sensitivity C-reactive protein level (P<0.001), uric acid level (P=0.004), adiponectin level (P<0.001), and left ventricular ejection fraction (P<0.001). Kaplan–Meier analysis indicated a significant difference in survival rate of patients in EATV quartile 1 versus 4 (P=0.019). After adjusting for confounding factors, EATV quartile 4 (>216.15 cm(3)) was still associated with adverse cardiovascular outcomes (HR = 1.98, 95% CI: 1.15–4.47, P=0.023) compared with quartile 1 (<101.58 cm(3)). Our data suggest that EATV is an independent predictor of long-term major adverse cardiovascular events in CHD patients after PCI. Therefore, assessment of EATV using multi-slice computed tomography may contribute to risk stratification in these patients. |
format | Online Article Text |
id | pubmed-6504663 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65046632019-05-20 Association between epicardial adipose tissue and adverse outcomes in coronary heart disease patients with percutaneous coronary intervention Lu, Changqing Jia, Helei Wang, Zhentao Biosci Rep Research Articles We assessed the relationship between the volume of epicardial adipose tissue and long-term outcomes in patients with coronary heart disease (CHD) undergoing percutaneous coronary intervention (PCI). The patients with CHD were followed for at least 2 years after PCI. The epicardial adipose tissue volume (EATV) was measured using multi-slice computed tomography. Cox regression analysis was used to examine the relationship between EATV and clinical outcome. In this study, 500 patients were enrolled and followed up for a median of 25.2 months. The incidence of adverse cardiovascular events was 12.4%. No significant differences were observed in age, sex, proportion of patients with hypertension or diabetes, smoking, drinking, total cholesterol, triglyceride, high-density lipoprotein, or unstable angina pectoris among different EATV quartiles (P>0.05). The EATV was associated with body mass index (P<0.0001), low-density lipoprotein level (P=0.039), high-sensitivity C-reactive protein level (P<0.001), uric acid level (P=0.004), adiponectin level (P<0.001), and left ventricular ejection fraction (P<0.001). Kaplan–Meier analysis indicated a significant difference in survival rate of patients in EATV quartile 1 versus 4 (P=0.019). After adjusting for confounding factors, EATV quartile 4 (>216.15 cm(3)) was still associated with adverse cardiovascular outcomes (HR = 1.98, 95% CI: 1.15–4.47, P=0.023) compared with quartile 1 (<101.58 cm(3)). Our data suggest that EATV is an independent predictor of long-term major adverse cardiovascular events in CHD patients after PCI. Therefore, assessment of EATV using multi-slice computed tomography may contribute to risk stratification in these patients. Portland Press Ltd. 2019-05-07 /pmc/articles/PMC6504663/ /pubmed/30979830 http://dx.doi.org/10.1042/BSR20182278 Text en © 2019 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Articles Lu, Changqing Jia, Helei Wang, Zhentao Association between epicardial adipose tissue and adverse outcomes in coronary heart disease patients with percutaneous coronary intervention |
title | Association between epicardial adipose tissue and adverse outcomes in coronary heart disease patients with percutaneous coronary intervention |
title_full | Association between epicardial adipose tissue and adverse outcomes in coronary heart disease patients with percutaneous coronary intervention |
title_fullStr | Association between epicardial adipose tissue and adverse outcomes in coronary heart disease patients with percutaneous coronary intervention |
title_full_unstemmed | Association between epicardial adipose tissue and adverse outcomes in coronary heart disease patients with percutaneous coronary intervention |
title_short | Association between epicardial adipose tissue and adverse outcomes in coronary heart disease patients with percutaneous coronary intervention |
title_sort | association between epicardial adipose tissue and adverse outcomes in coronary heart disease patients with percutaneous coronary intervention |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504663/ https://www.ncbi.nlm.nih.gov/pubmed/30979830 http://dx.doi.org/10.1042/BSR20182278 |
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