Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8(+) T Cell Activation via Cross-Presentation in Type 1 Diabetes

Aims: Reactive oxygen species (ROS) are critical in driving the onset of type 1 diabetes (T1D). Ablation of ROS derived from phagocytic NADPH oxidase 2 is protective against autoimmune diabetes in non-obese diabetic (NOD) mice. However, the mechanisms of NADPH oxidase 2-derived ROS in T1D pathogenes...

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Detalles Bibliográficos
Autores principales: Liu, Chao, Whitener, Robert L., Lin, Andrea, Xu, Yuan, Chen, Jing, Savinov, Alexei, Leiding, Jennifer W., Wallet, Mark A., Mathews, Clayton E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504685/
https://www.ncbi.nlm.nih.gov/pubmed/31118934
http://dx.doi.org/10.3389/fimmu.2019.00952

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504685/
https://www.ncbi.nlm.nih.gov/pubmed/31118934
http://dx.doi.org/10.3389/fimmu.2019.00952

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