Dopamine Receptor D3 Expression Is Altered in CD4(+) T-Cells From Parkinson's Disease Patients and Its Pharmacologic Inhibition Attenuates the Motor Impairment in a Mouse Model

Neuroinflammation constitutes a fundamental process involved in Parkinson's disease (PD). Microglial cells play a central role in the outcome of neuroinflammation and consequent neurodegeneration of dopaminergic neurons in the substantia nigra. Current evidence indicates that CD4(+) T-cells inf...

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Detalles Bibliográficos
Autores principales: Elgueta, Daniela, Contreras, Francisco, Prado, Carolina, Montoya, Andro, Ugalde, Valentina, Chovar, Ornella, Villagra, Roque, Henríquez, Claudio, Abellanas, Miguel A., Aymerich, María S., Franco, Rarael, Pacheco, Rodrigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504698/
https://www.ncbi.nlm.nih.gov/pubmed/31118938
http://dx.doi.org/10.3389/fimmu.2019.00981

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