Cargando…

GRK Mediates μ-Opioid Receptor Plasma Membrane Reorganization

Differential regulation of the μ-opioid receptor (MOP) has been linked to the development of opioid tolerance and dependence which both limit the clinical use of opioid analgesics. At a cellular level, MOP regulation occurs via receptor phosphorylation, desensitization, plasma membrane redistributio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gondin, Arisbel B., Halls, Michelle L., Canals, Meritxell, Briddon, Stephen J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504784/ https://www.ncbi.nlm.nih.gov/pubmed/31118885 http://dx.doi.org/10.3389/fnmol.2019.00104

Ejemplares similares

Ligand-dependent spatiotemporal signaling profiles of the μ-opioid receptor are controlled by distinct protein-interaction networks
por: Civciristov, Srgjan, et al.
Publicado: (2019)

A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes
por: Mai, Quynh N., et al.
Publicado: (2021)

Co-Expression of GRK2 Reveals a Novel Conformational State of the µ-Opioid Receptor
por: Nickolls, Sarah A., et al.
Publicado: (2013)

Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells
por: Møller, Thor C., et al.
Publicado: (2020)

Efficient G protein coupling is not required for agonist‐mediated internalization and membrane reorganization of the adenosine A(3) receptor
por: Stoddart, Leigh A., et al.
Publicado: (2021)

Cellular tolerance at the µ-opioid receptor is phosphorylation dependent
por: Arttamangkul, Seksiri, et al.
Publicado: (2018)

New phosphosite-specific antibodies to unravel the role of GRK phosphorylation in dopamine D(2) receptor regulation and signaling
por: Mann, Anika, et al.
Publicado: (2021)

Opioids, sleep, analgesia and respiratory depression: Their convergence on Mu (μ)-opioid receptors in the parabrachial area
por: Lynch, Nicole, et al.
Publicado: (2023)

GRKs as Key Modulators of Opioid Receptor Function
por: Lemel, Laura, et al.
Publicado: (2020)

Antagonistic Roles of GRK2 and GRK5 in Cardiac Aldosterone Signaling Reveal GRK5-Mediated Cardioprotection via Mineralocorticoid Receptor Inhibition
por: Maning, Jennifer, et al.
Publicado: (2020)

Inhibition of GABAergic Neurotransmission by HIV-1 Tat and Opioid Treatment in the Striatum Involves μ-Opioid Receptors
por: Xu, Changqing, et al.
Publicado: (2016)

Opposite Roles of δ- and μ-Opioid Receptors in BACE1 Regulation and Alzheimer’s Injury
por: Xu, Yuan, et al.
Publicado: (2020)

Functional independence of endogenous μ- and δ-opioid receptors co-expressed in cholinergic interneurons
por: Arttamangkul, Seksiri, et al.
Publicado: (2021)

Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells
por: Stoeber, Miriam, et al.
Publicado: (2020)

Decreased Endomorphin-2 and μ-Opioid Receptor in the Spinal Cord Are Associated with Painful Diabetic Neuropathy
por: Kou, Zhen-Zhen, et al.
Publicado: (2016)

State-dependent μ-opioid modulation of social motivation
por: Loseth, Guro E., et al.
Publicado: (2014)

μ-opioid receptor system mediates reward processing in humans
por: Nummenmaa, Lauri, et al.
Publicado: (2018)

Opioid Receptor-Mediated Regulation of Neurotransmission in the Brain
por: Reeves, Kaitlin C., et al.
Publicado: (2022)

A tetrapeptide class of biased analgesics from an Australian fungus targets the µ-opioid receptor
por: Dekan, Zoltan, et al.
Publicado: (2019)

Racemic Salsolinol and its Enantiomers Act as Agonists of the μ-Opioid Receptor by Activating the Gi Protein-Adenylate Cyclase Pathway
por: Berríos-Cárcamo, Pablo, et al.
Publicado: (2017)

Impact of Lipid Composition and Receptor Conformation on the Spatio-temporal Organization of μ-Opioid Receptors in a Multi-component Plasma Membrane Model
por: Marino, Kristen A., et al.
Publicado: (2016)

β-Arrestin 2 and ERK1/2 Are Important Mediators Engaged in Close Cooperation between TRPV1 and µ-Opioid Receptors in the Plasma Membrane
por: Melkes, Barbora, et al.
Publicado: (2020)

Quantitative Detection of µ Opioid Receptor: Western Blot Analyses Using µ Opioid Receptor Knockout Mice
por: Kasai, Shinya, et al.
Publicado: (2011)

Human μ Opioid Receptor Models with Evaluation of the Accuracy Using the Crystal Structure of the Murine μ Opioid Receptor
por: Perez-Aguilar, Jose Manuel, et al.
Publicado: (2012)

Structural insights into μ-opioid receptor activation
por: Huang, Weijiao, et al.
Publicado: (2015)

Negative modulation of spinal κ-opioid receptor-mediated antinociception by the µ-opioid receptor at selective doses of (−)-pentazocine
por: Robinson, Douglas L., et al.
Publicado: (2018)

G Protein-Coupled Receptor Kinase 2 (GRK2) and 5 (GRK5) Exhibit Selective Phosphorylation of the Neurotensin Receptor in Vitro
por: Inagaki, Sayaka, et al.
Publicado: (2015)

Proposed Mode of Binding and Action of Positive Allosteric Modulators at Opioid Receptors
por: Shang, Yi, et al.
Publicado: (2016)

Effect of the 5-HT(4) receptor agonist tegaserod on the expression of GRK2 and GRK6 in the rat gastrointestinal tract
por: Nedi, Teshome, et al.
Publicado: (2018)

Synthesis and Evaluation of Novel Biased μ-Opioid-Receptor (μOR) Agonists
por: Ma, Mengjun, et al.
Publicado: (2019)

Heteromerization of μ-opioid receptor and cholecystokinin B receptor through the third transmembrane domain of the μ-opioid receptor contributes to the anti-opioid effects of cholecystokinin octapeptide
por: Yang, Yin, et al.
Publicado: (2018)

Trafficking GRK2: Cellular and Metabolic consequences of GRK2 subcellular localization.
por: Sorriento, Daniela, et al.
Publicado: (2014)

Suitability of GRK Antibodies for Individual Detection and Quantification of GRK Isoforms in Western Blots
por: Reichel, Mona, et al.
Publicado: (2022)

Correction: Maning et al. Antagonistic Roles of GRK2 and GRK5 in Cardiac Aldosterone Signaling Reveal GRK5-Mediated Cardioprotection via Mineralocorticoid Receptor Inhibition. Int. J. Mol. Sci. 2020, 21, 2868
por: Maning, Jennifer, et al.
Publicado: (2021)

Palmitoylation and membrane cholesterol stabilize μ-opioid receptor homodimerization and G protein coupling
por: Zheng, Hui, et al.
Publicado: (2012)

μ-Opioid Receptors on Distinct Neuronal Populations Mediate Different Aspects of Opioid Reward-Related Behaviors
por: Severino, Amie L., et al.
Publicado: (2020)

Signaling underlying kappa opioid receptor-mediated behaviors in rodents
por: Liu-Chen, Lee-Yuan, et al.
Publicado: (2022)

Modulation of CXCR4-Mediated Gi1 Activation by EGF Receptor and GRK2
por: Neves, Maria, et al.
Publicado: (2020)

Activation of μ-opioid receptors inhibits calcium-currents in the vestibular afferent neurons of the rat through a cAMP dependent mechanism
por: Seseña, Emmanuel, et al.
Publicado: (2014)

Acute Stress Facilitates LTD Induction at Glutamatergic Synapses in the Hippocampal CA1 Region by Activating μ-Opioid Receptors on GABAergic Neurons
por: Fan, Ka-Min, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_k12t97tcpj06pkdsc8nv3vr097