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Characterization of Eptesipoxvirus, a novel poxvirus from a microchiropteran bat
The genome of Eptesipoxvirus (EPTV) is the first poxvirus genome isolated from a microbat. The 176,688 nt sequence, which is believed to encompass the complete coding region of the virus, is 67% A+T and is predicted to encode 191 genes. 11 of these genes have no counterpart in GenBank and are theref...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504846/ https://www.ncbi.nlm.nih.gov/pubmed/28685222 http://dx.doi.org/10.1007/s11262-017-1485-4 |
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author | Tu, Shin-Lin Nakazawa, Yoshinori Gao, Jinxin Wilkins, Kimberly Gallardo-Romero, Nadia Li, Yu Emerson, Ginny L. Carroll, Darin S. Upton, Chris |
author_facet | Tu, Shin-Lin Nakazawa, Yoshinori Gao, Jinxin Wilkins, Kimberly Gallardo-Romero, Nadia Li, Yu Emerson, Ginny L. Carroll, Darin S. Upton, Chris |
author_sort | Tu, Shin-Lin |
collection | PubMed |
description | The genome of Eptesipoxvirus (EPTV) is the first poxvirus genome isolated from a microbat. The 176,688 nt sequence, which is believed to encompass the complete coding region of the virus, is 67% A+T and is predicted to encode 191 genes. 11 of these genes have no counterpart in GenBank and are therefore unique to EPTV. The presence of a distantly related ortholog of Vaccinia virus F5L in EPTV uncovered a link with fragmented F5L orthologs in Molluscum contagiosum virus/squirrelpox and clade II viruses. Consistent with the unique position of EPTV approximately mid-point between the orthopoxviruses and the clade II viruses, EPTV has 11 genes that are specific to the orthopoxviruses and 13 genes that are typical, if not exclusive, to the clade II poxviruses. This mosaic nature of EPTV blurs the distinction between the old description of the orthopoxvirus and clade II groups. Genome annotation and characterization failed to find any common virulence genes shared with the other poxvirus isolated from bat (pteropoxvirus); however, EPTV encodes 3 genes that may have been transferred to or from deerpox and squirrelpox viruses; 2 of these, a putative endothelin-like protein and a MHC class I-like protein are likely to have immunomodulatory roles. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11262-017-1485-4) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-6504846 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-65048462019-05-08 Characterization of Eptesipoxvirus, a novel poxvirus from a microchiropteran bat Tu, Shin-Lin Nakazawa, Yoshinori Gao, Jinxin Wilkins, Kimberly Gallardo-Romero, Nadia Li, Yu Emerson, Ginny L. Carroll, Darin S. Upton, Chris Virus Genes Article The genome of Eptesipoxvirus (EPTV) is the first poxvirus genome isolated from a microbat. The 176,688 nt sequence, which is believed to encompass the complete coding region of the virus, is 67% A+T and is predicted to encode 191 genes. 11 of these genes have no counterpart in GenBank and are therefore unique to EPTV. The presence of a distantly related ortholog of Vaccinia virus F5L in EPTV uncovered a link with fragmented F5L orthologs in Molluscum contagiosum virus/squirrelpox and clade II viruses. Consistent with the unique position of EPTV approximately mid-point between the orthopoxviruses and the clade II viruses, EPTV has 11 genes that are specific to the orthopoxviruses and 13 genes that are typical, if not exclusive, to the clade II poxviruses. This mosaic nature of EPTV blurs the distinction between the old description of the orthopoxvirus and clade II groups. Genome annotation and characterization failed to find any common virulence genes shared with the other poxvirus isolated from bat (pteropoxvirus); however, EPTV encodes 3 genes that may have been transferred to or from deerpox and squirrelpox viruses; 2 of these, a putative endothelin-like protein and a MHC class I-like protein are likely to have immunomodulatory roles. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11262-017-1485-4) contains supplementary material, which is available to authorized users. Springer US 2017-07-06 2017 /pmc/articles/PMC6504846/ /pubmed/28685222 http://dx.doi.org/10.1007/s11262-017-1485-4 Text en © Springer Science+Business Media, LLC 2017 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Tu, Shin-Lin Nakazawa, Yoshinori Gao, Jinxin Wilkins, Kimberly Gallardo-Romero, Nadia Li, Yu Emerson, Ginny L. Carroll, Darin S. Upton, Chris Characterization of Eptesipoxvirus, a novel poxvirus from a microchiropteran bat |
title | Characterization of Eptesipoxvirus, a novel poxvirus from a microchiropteran bat |
title_full | Characterization of Eptesipoxvirus, a novel poxvirus from a microchiropteran bat |
title_fullStr | Characterization of Eptesipoxvirus, a novel poxvirus from a microchiropteran bat |
title_full_unstemmed | Characterization of Eptesipoxvirus, a novel poxvirus from a microchiropteran bat |
title_short | Characterization of Eptesipoxvirus, a novel poxvirus from a microchiropteran bat |
title_sort | characterization of eptesipoxvirus, a novel poxvirus from a microchiropteran bat |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504846/ https://www.ncbi.nlm.nih.gov/pubmed/28685222 http://dx.doi.org/10.1007/s11262-017-1485-4 |
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