Cargando…

How cells fuse

Cell–cell fusion remains the least understood type of membrane fusion process. However, the last few years have brought about major advances in understanding fusion between gametes, myoblasts, macrophages, trophoblasts, epithelial, cancer, and other cells in normal development and in diseases. While...

Descripción completa

Detalles Bibliográficos
Autores principales: Brukman, Nicolas G., Uygur, Berna, Podbilewicz, Benjamin, Chernomordik, Leonid V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504885/
https://www.ncbi.nlm.nih.gov/pubmed/30936162
http://dx.doi.org/10.1083/jcb.201901017
_version_ 1783416654846230528
author Brukman, Nicolas G.
Uygur, Berna
Podbilewicz, Benjamin
Chernomordik, Leonid V.
author_facet Brukman, Nicolas G.
Uygur, Berna
Podbilewicz, Benjamin
Chernomordik, Leonid V.
author_sort Brukman, Nicolas G.
collection PubMed
description Cell–cell fusion remains the least understood type of membrane fusion process. However, the last few years have brought about major advances in understanding fusion between gametes, myoblasts, macrophages, trophoblasts, epithelial, cancer, and other cells in normal development and in diseases. While different cell fusion processes appear to proceed via similar membrane rearrangements, proteins that have been identified as necessary and sufficient for cell fusion (fusogens) use diverse mechanisms. Some fusions are controlled by a single fusogen; other fusions depend on several proteins that either work together throughout the fusion pathway or drive distinct stages. Furthermore, some fusions require fusogens to be present on both fusing membranes, and in other fusions, fusogens have to be on only one of the membranes. Remarkably, some of the proteins that fuse cells also sculpt single cells, repair neurons, promote scission of endocytic vesicles, and seal phagosomes. In this review, we discuss the properties and diversity of the known proteins mediating cell–cell fusion and highlight their different working mechanisms in various contexts.
format Online
Article
Text
id pubmed-6504885
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-65048852019-11-06 How cells fuse Brukman, Nicolas G. Uygur, Berna Podbilewicz, Benjamin Chernomordik, Leonid V. J Cell Biol Reviews Cell–cell fusion remains the least understood type of membrane fusion process. However, the last few years have brought about major advances in understanding fusion between gametes, myoblasts, macrophages, trophoblasts, epithelial, cancer, and other cells in normal development and in diseases. While different cell fusion processes appear to proceed via similar membrane rearrangements, proteins that have been identified as necessary and sufficient for cell fusion (fusogens) use diverse mechanisms. Some fusions are controlled by a single fusogen; other fusions depend on several proteins that either work together throughout the fusion pathway or drive distinct stages. Furthermore, some fusions require fusogens to be present on both fusing membranes, and in other fusions, fusogens have to be on only one of the membranes. Remarkably, some of the proteins that fuse cells also sculpt single cells, repair neurons, promote scission of endocytic vesicles, and seal phagosomes. In this review, we discuss the properties and diversity of the known proteins mediating cell–cell fusion and highlight their different working mechanisms in various contexts. Rockefeller University Press 2019-05-06 2019-04-01 /pmc/articles/PMC6504885/ /pubmed/30936162 http://dx.doi.org/10.1083/jcb.201901017 Text en © 2019 Brukman et al. http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Reviews
Brukman, Nicolas G.
Uygur, Berna
Podbilewicz, Benjamin
Chernomordik, Leonid V.
How cells fuse
title How cells fuse
title_full How cells fuse
title_fullStr How cells fuse
title_full_unstemmed How cells fuse
title_short How cells fuse
title_sort how cells fuse
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504885/
https://www.ncbi.nlm.nih.gov/pubmed/30936162
http://dx.doi.org/10.1083/jcb.201901017
work_keys_str_mv AT brukmannicolasg howcellsfuse
AT uygurberna howcellsfuse
AT podbilewiczbenjamin howcellsfuse
AT chernomordikleonidv howcellsfuse