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How cells fuse
Cell–cell fusion remains the least understood type of membrane fusion process. However, the last few years have brought about major advances in understanding fusion between gametes, myoblasts, macrophages, trophoblasts, epithelial, cancer, and other cells in normal development and in diseases. While...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504885/ https://www.ncbi.nlm.nih.gov/pubmed/30936162 http://dx.doi.org/10.1083/jcb.201901017 |
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author | Brukman, Nicolas G. Uygur, Berna Podbilewicz, Benjamin Chernomordik, Leonid V. |
author_facet | Brukman, Nicolas G. Uygur, Berna Podbilewicz, Benjamin Chernomordik, Leonid V. |
author_sort | Brukman, Nicolas G. |
collection | PubMed |
description | Cell–cell fusion remains the least understood type of membrane fusion process. However, the last few years have brought about major advances in understanding fusion between gametes, myoblasts, macrophages, trophoblasts, epithelial, cancer, and other cells in normal development and in diseases. While different cell fusion processes appear to proceed via similar membrane rearrangements, proteins that have been identified as necessary and sufficient for cell fusion (fusogens) use diverse mechanisms. Some fusions are controlled by a single fusogen; other fusions depend on several proteins that either work together throughout the fusion pathway or drive distinct stages. Furthermore, some fusions require fusogens to be present on both fusing membranes, and in other fusions, fusogens have to be on only one of the membranes. Remarkably, some of the proteins that fuse cells also sculpt single cells, repair neurons, promote scission of endocytic vesicles, and seal phagosomes. In this review, we discuss the properties and diversity of the known proteins mediating cell–cell fusion and highlight their different working mechanisms in various contexts. |
format | Online Article Text |
id | pubmed-6504885 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-65048852019-11-06 How cells fuse Brukman, Nicolas G. Uygur, Berna Podbilewicz, Benjamin Chernomordik, Leonid V. J Cell Biol Reviews Cell–cell fusion remains the least understood type of membrane fusion process. However, the last few years have brought about major advances in understanding fusion between gametes, myoblasts, macrophages, trophoblasts, epithelial, cancer, and other cells in normal development and in diseases. While different cell fusion processes appear to proceed via similar membrane rearrangements, proteins that have been identified as necessary and sufficient for cell fusion (fusogens) use diverse mechanisms. Some fusions are controlled by a single fusogen; other fusions depend on several proteins that either work together throughout the fusion pathway or drive distinct stages. Furthermore, some fusions require fusogens to be present on both fusing membranes, and in other fusions, fusogens have to be on only one of the membranes. Remarkably, some of the proteins that fuse cells also sculpt single cells, repair neurons, promote scission of endocytic vesicles, and seal phagosomes. In this review, we discuss the properties and diversity of the known proteins mediating cell–cell fusion and highlight their different working mechanisms in various contexts. Rockefeller University Press 2019-05-06 2019-04-01 /pmc/articles/PMC6504885/ /pubmed/30936162 http://dx.doi.org/10.1083/jcb.201901017 Text en © 2019 Brukman et al. http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Reviews Brukman, Nicolas G. Uygur, Berna Podbilewicz, Benjamin Chernomordik, Leonid V. How cells fuse |
title | How cells fuse |
title_full | How cells fuse |
title_fullStr | How cells fuse |
title_full_unstemmed | How cells fuse |
title_short | How cells fuse |
title_sort | how cells fuse |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504885/ https://www.ncbi.nlm.nih.gov/pubmed/30936162 http://dx.doi.org/10.1083/jcb.201901017 |
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