A CRACker of an adaptor connects dynein-mediated transport to calcium signaling

Many different adaptor proteins activate the processivity of dynein–dynactin complexes and determine the specific cargo for retrograde transport by binding cargo receptors such as Rab GTP-binding (G) proteins. In this issue, Wang et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201806097) ide...

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Detalles Bibliográficos
Autores principales: Sharma, Mahak, Dwivedi, Devashish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504887/
https://www.ncbi.nlm.nih.gov/pubmed/31010854
http://dx.doi.org/10.1083/jcb.201904069
Descripción
Sumario:Many different adaptor proteins activate the processivity of dynein–dynactin complexes and determine the specific cargo for retrograde transport by binding cargo receptors such as Rab GTP-binding (G) proteins. In this issue, Wang et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201806097) identify two GTPases that can function directly as dynein adaptors during endocytosis and are regulated by calcium.

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