Neurons regulate synaptic strength through homeostatic scaling of active zones

How neurons stabilize their overall synaptic strength following conditions that alter synaptic morphology or function is a key question in neuronal homeostasis. In this issue, Goel et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201807165) find that neurons stabilize synaptic output despite...

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Detalles Bibliográficos
Autores principales: Cunningham, Karen L., Littleton, J. Troy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504892/
https://www.ncbi.nlm.nih.gov/pubmed/30979798
http://dx.doi.org/10.1083/jcb.201903065
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author Cunningham, Karen L.
Littleton, J. Troy
author_facet Cunningham, Karen L.
Littleton, J. Troy
author_sort Cunningham, Karen L.
collection PubMed
description How neurons stabilize their overall synaptic strength following conditions that alter synaptic morphology or function is a key question in neuronal homeostasis. In this issue, Goel et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201807165) find that neurons stabilize synaptic output despite disruptions in synapse size, active zone number, or postsynaptic function by controlling the delivery of active zone material and active zone size.
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spelling pubmed-65048922019-11-06 Neurons regulate synaptic strength through homeostatic scaling of active zones Cunningham, Karen L. Littleton, J. Troy J Cell Biol Commentaries How neurons stabilize their overall synaptic strength following conditions that alter synaptic morphology or function is a key question in neuronal homeostasis. In this issue, Goel et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201807165) find that neurons stabilize synaptic output despite disruptions in synapse size, active zone number, or postsynaptic function by controlling the delivery of active zone material and active zone size. Rockefeller University Press 2019-05-06 2019-04-12 /pmc/articles/PMC6504892/ /pubmed/30979798 http://dx.doi.org/10.1083/jcb.201903065 Text en © 2019 Cunningham and Littleton http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentaries
Cunningham, Karen L.
Littleton, J. Troy
Neurons regulate synaptic strength through homeostatic scaling of active zones
title Neurons regulate synaptic strength through homeostatic scaling of active zones
title_full Neurons regulate synaptic strength through homeostatic scaling of active zones
title_fullStr Neurons regulate synaptic strength through homeostatic scaling of active zones
title_full_unstemmed Neurons regulate synaptic strength through homeostatic scaling of active zones
title_short Neurons regulate synaptic strength through homeostatic scaling of active zones
title_sort neurons regulate synaptic strength through homeostatic scaling of active zones
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504892/
https://www.ncbi.nlm.nih.gov/pubmed/30979798
http://dx.doi.org/10.1083/jcb.201903065
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