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Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response
T cells expressing CD19-targeting chimeric antigen receptors (CARs) reveal high efficacy in the treatment of B cell malignancies. Here, we report that T cell receptor fusion constructs (TRuCs) comprising an antibody-based binding domain fused to T cell receptor (TCR) subunits can effectively reprogr...
Autores principales: | Baeuerle, Patrick A., Ding, Jian, Patel, Ekta, Thorausch, Niko, Horton, Holly, Gierut, Jessica, Scarfo, Irene, Choudhary, Rashmi, Kiner, Olga, Krishnamurthy, Janani, Le, Bonnie, Morath, Anna, Baldeviano, G. Christian, Quinn, Justin, Tavares, Patrick, Wei, Qi, Weiler, Solly, Maus, Marcela V., Getts, Daniel, Schamel, Wolfgang W., Hofmeister, Robert |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504948/ https://www.ncbi.nlm.nih.gov/pubmed/31064990 http://dx.doi.org/10.1038/s41467-019-10097-0 |
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