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Influence of anti-tumor necrosis factor-alpha therapy to pregnant inflammatory bowel disease women and their children’s immunity

BACKGROUND/AIMS: The onset of inflammatory bowel disease (IBD) usually occurs at young age, and therefore, women IBD patients experience pregnancy during their disease progression. Recently, the use of anti-tumor necrosis factor-α (anti-TNF-α) has been rapidly increasing. The aim of this study was t...

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Autores principales: Lee, Ko Eun, Jung, Sung-Ae, Park, Sang Hyoung, Moon, Chang Mo, Shim, So Yeon, Kim, Eun Soo, Cho, Su Jin, Kim, Seong-Eun, Cho, Kwang Bum, Yang, Suk-Kyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association for the Study of Intestinal Diseases 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505087/
https://www.ncbi.nlm.nih.gov/pubmed/30727711
http://dx.doi.org/10.5217/ir.2018.00071
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author Lee, Ko Eun
Jung, Sung-Ae
Park, Sang Hyoung
Moon, Chang Mo
Shim, So Yeon
Kim, Eun Soo
Cho, Su Jin
Kim, Seong-Eun
Cho, Kwang Bum
Yang, Suk-Kyun
author_facet Lee, Ko Eun
Jung, Sung-Ae
Park, Sang Hyoung
Moon, Chang Mo
Shim, So Yeon
Kim, Eun Soo
Cho, Su Jin
Kim, Seong-Eun
Cho, Kwang Bum
Yang, Suk-Kyun
author_sort Lee, Ko Eun
collection PubMed
description BACKGROUND/AIMS: The onset of inflammatory bowel disease (IBD) usually occurs at young age, and therefore, women IBD patients experience pregnancy during their disease progression. Recently, the use of anti-tumor necrosis factor-α (anti-TNF-α) has been rapidly increasing. The aim of this study was to evaluate pregnancy related outcomes in women with IBD who were treated with anti-TNF-α during pregnancy and immunity of their children. METHODS: Korean women with IBD who had been treated with anti-TNF-α during pregnancy had been enrolled. Medical records were reviewed and a survey was performed for each patient. For the patients who agreed on additional examination for their children, children’s growth, medical history and antibody to hepatitis B surface antigen (anti-HBs) titer were checked. RESULTS: All 18 patients had been diagnosed with Crohn’s disease. There was not any case of preterm delivery, low birth-weight infant, congenital anomaly, nor stillbirth. All 12 children had followed the regular vaccination schedule for hepatitis B and 4 of them showed negative results for anti-HBs. After the 1 booster vaccination, all children demonstrated seroconversion. Regarding live vaccines, 4 children had bacillus Calmette-Guerin and 4 had rotavirus vaccine before 6 months, without any specific side effects. CONCLUSIONS: This was the first study of immunity of the children born from IBD women who had been treated with anti-TNF-α medication during their pregnancy. IBD women had comparable pregnancy outcomes with the general women population, suggesting that the disease activity rather than the administered medication would be more important in healthy pregnancy. Considering the history of vaccination and anti-HBs titers, immunity seems to be intact in the children.
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spelling pubmed-65050872019-05-20 Influence of anti-tumor necrosis factor-alpha therapy to pregnant inflammatory bowel disease women and their children’s immunity Lee, Ko Eun Jung, Sung-Ae Park, Sang Hyoung Moon, Chang Mo Shim, So Yeon Kim, Eun Soo Cho, Su Jin Kim, Seong-Eun Cho, Kwang Bum Yang, Suk-Kyun Intest Res Original Article BACKGROUND/AIMS: The onset of inflammatory bowel disease (IBD) usually occurs at young age, and therefore, women IBD patients experience pregnancy during their disease progression. Recently, the use of anti-tumor necrosis factor-α (anti-TNF-α) has been rapidly increasing. The aim of this study was to evaluate pregnancy related outcomes in women with IBD who were treated with anti-TNF-α during pregnancy and immunity of their children. METHODS: Korean women with IBD who had been treated with anti-TNF-α during pregnancy had been enrolled. Medical records were reviewed and a survey was performed for each patient. For the patients who agreed on additional examination for their children, children’s growth, medical history and antibody to hepatitis B surface antigen (anti-HBs) titer were checked. RESULTS: All 18 patients had been diagnosed with Crohn’s disease. There was not any case of preterm delivery, low birth-weight infant, congenital anomaly, nor stillbirth. All 12 children had followed the regular vaccination schedule for hepatitis B and 4 of them showed negative results for anti-HBs. After the 1 booster vaccination, all children demonstrated seroconversion. Regarding live vaccines, 4 children had bacillus Calmette-Guerin and 4 had rotavirus vaccine before 6 months, without any specific side effects. CONCLUSIONS: This was the first study of immunity of the children born from IBD women who had been treated with anti-TNF-α medication during their pregnancy. IBD women had comparable pregnancy outcomes with the general women population, suggesting that the disease activity rather than the administered medication would be more important in healthy pregnancy. Considering the history of vaccination and anti-HBs titers, immunity seems to be intact in the children. Korean Association for the Study of Intestinal Diseases 2019-04 2019-02-08 /pmc/articles/PMC6505087/ /pubmed/30727711 http://dx.doi.org/10.5217/ir.2018.00071 Text en © Copyright 2019. Korean Association for the Study of Intestinal Diseases. All rights reserved. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lee, Ko Eun
Jung, Sung-Ae
Park, Sang Hyoung
Moon, Chang Mo
Shim, So Yeon
Kim, Eun Soo
Cho, Su Jin
Kim, Seong-Eun
Cho, Kwang Bum
Yang, Suk-Kyun
Influence of anti-tumor necrosis factor-alpha therapy to pregnant inflammatory bowel disease women and their children’s immunity
title Influence of anti-tumor necrosis factor-alpha therapy to pregnant inflammatory bowel disease women and their children’s immunity
title_full Influence of anti-tumor necrosis factor-alpha therapy to pregnant inflammatory bowel disease women and their children’s immunity
title_fullStr Influence of anti-tumor necrosis factor-alpha therapy to pregnant inflammatory bowel disease women and their children’s immunity
title_full_unstemmed Influence of anti-tumor necrosis factor-alpha therapy to pregnant inflammatory bowel disease women and their children’s immunity
title_short Influence of anti-tumor necrosis factor-alpha therapy to pregnant inflammatory bowel disease women and their children’s immunity
title_sort influence of anti-tumor necrosis factor-alpha therapy to pregnant inflammatory bowel disease women and their children’s immunity
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505087/
https://www.ncbi.nlm.nih.gov/pubmed/30727711
http://dx.doi.org/10.5217/ir.2018.00071
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