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Abdominal ultrasonography with color Doppler analysis in the assessment of ileal Crohn’s disease: comparison with magnetic resonance enterography

BACKGROUND/AIMS: Consistently defining disease activity remains a critical challenge in the follow-up of patients with Crohn’s disease (CD). We investigated the potential applicability of abdominal ultrasonography with color Doppler (USCD) analysis for the detection of morphological alterations and...

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Autores principales: da Silva Moraes, Antonio Carlos, de Freitas Moraes, Glycia, de Araújo, Antonio Luis Eiras, Luiz, Ronir Raggio, Elia, Celeste, Carneiro, Antonio Jose, de Souza, Heitor Siffert Pereira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association for the Study of Intestinal Diseases 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505095/
https://www.ncbi.nlm.nih.gov/pubmed/30962408
http://dx.doi.org/10.5217/ir.2018.00124
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author da Silva Moraes, Antonio Carlos
de Freitas Moraes, Glycia
de Araújo, Antonio Luis Eiras
Luiz, Ronir Raggio
Elia, Celeste
Carneiro, Antonio Jose
de Souza, Heitor Siffert Pereira
author_facet da Silva Moraes, Antonio Carlos
de Freitas Moraes, Glycia
de Araújo, Antonio Luis Eiras
Luiz, Ronir Raggio
Elia, Celeste
Carneiro, Antonio Jose
de Souza, Heitor Siffert Pereira
author_sort da Silva Moraes, Antonio Carlos
collection PubMed
description BACKGROUND/AIMS: Consistently defining disease activity remains a critical challenge in the follow-up of patients with Crohn’s disease (CD). We investigated the potential applicability of abdominal ultrasonography with color Doppler (USCD) analysis for the detection of morphological alterations and inflammatory activity in CD. METHODS: Forty-three patients with CD ileitis/ileocolitis were evaluated using USCD analysis with measurements obtained on the terminal ileum and right colon. Sonographic parameters included wall thickening, stricture, hyperemia, presence of intra-abdominal mass, and fistulas. Patients were evaluated for the clinical activity (Harvey-Bradshaw Index [HBI]), fecal calprotectin (FC) and C-reactive protein (CRP). The USCD performance was assessed using magnetic resonance enterography (MRE) as a criterion standard. RESULTS: Most measurements obtained with USCD matched the data generated with MRE; however, the agreement improved in clinically active patients where sensitivity, positive predictive value, and accuracy were >80%, considering wall thickening and hyperemia. Complications such as intestinal wall thickening, stricture formation, and hyperemia, were detected in the USCD analysis with moderate agreement with MRE. The best agreement with the USCD analysis was obtained in regard to FC, where the sensitivity, positive predictive value, and accuracy were >70%. The overall performance of USCD was superior to that of HBI, FC and CRP levels, particularly when considering thickening, stricture, and hyperemia parameters. CONCLUSIONS: USCD represents a practical noninvasive and low-cost tool for evaluating patients with ileal or ileocolonic disease, particularly in clinically active CD. Therefore, USCD might become a useful asset in the follow-up of patients with CD.
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spelling pubmed-65050952019-05-20 Abdominal ultrasonography with color Doppler analysis in the assessment of ileal Crohn’s disease: comparison with magnetic resonance enterography da Silva Moraes, Antonio Carlos de Freitas Moraes, Glycia de Araújo, Antonio Luis Eiras Luiz, Ronir Raggio Elia, Celeste Carneiro, Antonio Jose de Souza, Heitor Siffert Pereira Intest Res Original Article BACKGROUND/AIMS: Consistently defining disease activity remains a critical challenge in the follow-up of patients with Crohn’s disease (CD). We investigated the potential applicability of abdominal ultrasonography with color Doppler (USCD) analysis for the detection of morphological alterations and inflammatory activity in CD. METHODS: Forty-three patients with CD ileitis/ileocolitis were evaluated using USCD analysis with measurements obtained on the terminal ileum and right colon. Sonographic parameters included wall thickening, stricture, hyperemia, presence of intra-abdominal mass, and fistulas. Patients were evaluated for the clinical activity (Harvey-Bradshaw Index [HBI]), fecal calprotectin (FC) and C-reactive protein (CRP). The USCD performance was assessed using magnetic resonance enterography (MRE) as a criterion standard. RESULTS: Most measurements obtained with USCD matched the data generated with MRE; however, the agreement improved in clinically active patients where sensitivity, positive predictive value, and accuracy were >80%, considering wall thickening and hyperemia. Complications such as intestinal wall thickening, stricture formation, and hyperemia, were detected in the USCD analysis with moderate agreement with MRE. The best agreement with the USCD analysis was obtained in regard to FC, where the sensitivity, positive predictive value, and accuracy were >70%. The overall performance of USCD was superior to that of HBI, FC and CRP levels, particularly when considering thickening, stricture, and hyperemia parameters. CONCLUSIONS: USCD represents a practical noninvasive and low-cost tool for evaluating patients with ileal or ileocolonic disease, particularly in clinically active CD. Therefore, USCD might become a useful asset in the follow-up of patients with CD. Korean Association for the Study of Intestinal Diseases 2019-04 2019-04-10 /pmc/articles/PMC6505095/ /pubmed/30962408 http://dx.doi.org/10.5217/ir.2018.00124 Text en © Copyright 2019. Korean Association for the Study of Intestinal Diseases. All rights reserved. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
da Silva Moraes, Antonio Carlos
de Freitas Moraes, Glycia
de Araújo, Antonio Luis Eiras
Luiz, Ronir Raggio
Elia, Celeste
Carneiro, Antonio Jose
de Souza, Heitor Siffert Pereira
Abdominal ultrasonography with color Doppler analysis in the assessment of ileal Crohn’s disease: comparison with magnetic resonance enterography
title Abdominal ultrasonography with color Doppler analysis in the assessment of ileal Crohn’s disease: comparison with magnetic resonance enterography
title_full Abdominal ultrasonography with color Doppler analysis in the assessment of ileal Crohn’s disease: comparison with magnetic resonance enterography
title_fullStr Abdominal ultrasonography with color Doppler analysis in the assessment of ileal Crohn’s disease: comparison with magnetic resonance enterography
title_full_unstemmed Abdominal ultrasonography with color Doppler analysis in the assessment of ileal Crohn’s disease: comparison with magnetic resonance enterography
title_short Abdominal ultrasonography with color Doppler analysis in the assessment of ileal Crohn’s disease: comparison with magnetic resonance enterography
title_sort abdominal ultrasonography with color doppler analysis in the assessment of ileal crohn’s disease: comparison with magnetic resonance enterography
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505095/
https://www.ncbi.nlm.nih.gov/pubmed/30962408
http://dx.doi.org/10.5217/ir.2018.00124
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