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Application of advanced brain positron emission tomography–based molecular imaging for a biological framework in neurodegenerative proteinopathies

INTRODUCTION: A rapid transition from a clinical-based classification to a pathology-based classification of neurodegenerative conditions, largely promoted by the increasing availability of imaging biomarkers, is emerging. The Framework for Innovative Multi-tracer molecular Brain Imaging, funded by...

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Detalles Bibliográficos
Autores principales: Perani, Daniela, Iaccarino, Leonardo, Jacobs, Andreas H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505113/
https://www.ncbi.nlm.nih.gov/pubmed/31080871
http://dx.doi.org/10.1016/j.dadm.2019.02.004
Descripción
Sumario:INTRODUCTION: A rapid transition from a clinical-based classification to a pathology-based classification of neurodegenerative conditions, largely promoted by the increasing availability of imaging biomarkers, is emerging. The Framework for Innovative Multi-tracer molecular Brain Imaging, funded by the EU Joint Program - Neurodegenerative Disease Research 2016 “Working Groups for Harmonisation and Alignment in Brain Imaging Methods for Neurodegeneration,” aimed at providing a roadmap for the applications of established and new molecular imaging techniques in dementia. METHODS: We consider current and future implications of adopting a pathology-based framework for the use and development of positron emission tomography techniques. RESULTS: This approach will enhance efforts to understand the multifactorial etiology of Alzheimer's disease and other dementias. DISCUSSION: The availability of pathology biomarkers will soon transform clinical and research practice. Crucially, a comprehensive understanding of strengths and caveats of these techniques will promote an informed use to take full advantage of these tools.