Identification of a Rat Mammary Tumor Risk Locus That Is Syntenic with the Commonly Amplified 8q12.1 and 8q22.1 Regions in Human Breast Cancer Patients

Breast cancer risk is 31% heritable, yet the majority of the underlying risk factors remain poorly defined. Here, we used F2-linkage analysis in a rat mammary tumor model to identify a novel 11.2 Mb modifier locus of tumor incidence and burden on rat chromosome 5 (chr5: 15.4 – 26.6 Mb). Genomic and...

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Detalles Bibliográficos
Autores principales: Plasterer, Cody, Tsaih, Shirng-Wern, Lemke, Angela, Schilling, Rebecca, Dwinell, Melinda, Rau, Andrea, Auer, Paul, Rui, Hallgeir, Flister, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2019
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505137/
https://www.ncbi.nlm.nih.gov/pubmed/30914425
http://dx.doi.org/10.1534/g3.118.200873

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505137/
https://www.ncbi.nlm.nih.gov/pubmed/30914425
http://dx.doi.org/10.1534/g3.118.200873

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