Two cases of intrahepatic cholangiocellular carcinoma with high insertion-deletion ratios that achieved a complete response following chemotherapy combined with PD-1 blockade

BACKGROUND: Insertion–deletion mutations (indels) may generate more tumour-specific neoantigens with high affinity to major histocompatibility complex class I. A high indel ratio is also related to a good response to programmed death-1 (PD-1) checkpoint blockade in melanoma and renal cell carcinoma....

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Detalles Bibliográficos
Autores principales: Sui, Minghao, Li, Yu, Wang, Hongguang, Luo, Ying, Wan, Tao, Wang, Xun, Hu, Bingyang, Cheng, Yanshuang, Lv, Xianrong, Xin, Xianlei, Xu, Qiang, Wang, Guan, Lu, Shichun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505215/
https://www.ncbi.nlm.nih.gov/pubmed/31064408
http://dx.doi.org/10.1186/s40425-019-0596-y

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