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UHRF1 depletion and HDAC inhibition reactivate epigenetically silenced genes in colorectal cancer cells
BACKGROUND: Ubiquitin-like protein containing PHD and RING finger domains 1 (UHRF1) is a major regulator of epigenetic mechanisms and is overexpressed in various human malignancies. In this study, we examined the involvement of UHRF1 in aberrant DNA methylation and gene silencing in colorectal cance...
Autores principales: | Niinuma, Takeshi, Kitajima, Hiroshi, Kai, Masahiro, Yamamoto, Eiichiro, Yorozu, Akira, Ishiguro, Kazuya, Sasaki, Hajime, Sudo, Gota, Toyota, Mutsumi, Hatahira, Tomo, Maruyama, Reo, Tokino, Takashi, Nakase, Hiroshi, Sugai, Tamotsu, Suzuki, Hiromu |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505222/ https://www.ncbi.nlm.nih.gov/pubmed/31064417 http://dx.doi.org/10.1186/s13148-019-0668-3 |
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