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Reduction in the rate of postoperative delirium by switching from famotidine to omeprazole in Japanese hepatectomized recipients

BACKGROUND: Hepatectomy is a highly invasive procedure with a high probability of postoperative delirium. Treatment with antiulcer drugs is indispensable after hepatectomy for anastomotic ulcer management. The clinical pathway for hepatectomy was reviewed and the antiulcer drug used was switched fro...

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Autores principales: Yamasaki, Miho, Fukuda, Yusa, Tanimoto, Aika, Narahara, Miko, Kawaguchi, Yumi, Ushiroda, Hiromi, Fukuda, Saburo, Murakami, Teruo, Maeda, Yorinobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505269/
https://www.ncbi.nlm.nih.gov/pubmed/31086675
http://dx.doi.org/10.1186/s40780-019-0139-1
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author Yamasaki, Miho
Fukuda, Yusa
Tanimoto, Aika
Narahara, Miko
Kawaguchi, Yumi
Ushiroda, Hiromi
Fukuda, Saburo
Murakami, Teruo
Maeda, Yorinobu
author_facet Yamasaki, Miho
Fukuda, Yusa
Tanimoto, Aika
Narahara, Miko
Kawaguchi, Yumi
Ushiroda, Hiromi
Fukuda, Saburo
Murakami, Teruo
Maeda, Yorinobu
author_sort Yamasaki, Miho
collection PubMed
description BACKGROUND: Hepatectomy is a highly invasive procedure with a high probability of postoperative delirium. Treatment with antiulcer drugs is indispensable after hepatectomy for anastomotic ulcer management. The clinical pathway for hepatectomy was reviewed and the antiulcer drug used was switched from famotidine, a H(2)-receptor antagonist, to omeprazole, a proton pump inhibitor, owing to the pharmacist’s intervention. METHODS: Hepatectomized recipients over 65 years of age, except in the cases of laparoscopic surgery and intensive care unit entry, were treated with famotidine injections (10 patients) or omeprazole injections (11 patients), and the incidence rates and severity of delirium were compared between the famotidine and omeprazole groups. The delirium after hepatectomy was assessed using the Japanese version of the NEECHAM confusion scale. RESULTS: The incidence rates of delirium were 90% in the famotidine group and 27.3% in the omeprazole group. Four out of 9 recipients in the famotidine group were injected with haloperidol to treat for delirium, but no recipients needed this treatment in the omeprazole group. CONCLUSIONS: Compared with famotidine, the use of omeprazole was found to be effective in reducing the incidence rate and severity of postoperative delirium in patients undergoing hepatectomy. Pharmacists should actively strive to mitigate the risks of delirium.
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spelling pubmed-65052692019-05-13 Reduction in the rate of postoperative delirium by switching from famotidine to omeprazole in Japanese hepatectomized recipients Yamasaki, Miho Fukuda, Yusa Tanimoto, Aika Narahara, Miko Kawaguchi, Yumi Ushiroda, Hiromi Fukuda, Saburo Murakami, Teruo Maeda, Yorinobu J Pharm Health Care Sci Research Article BACKGROUND: Hepatectomy is a highly invasive procedure with a high probability of postoperative delirium. Treatment with antiulcer drugs is indispensable after hepatectomy for anastomotic ulcer management. The clinical pathway for hepatectomy was reviewed and the antiulcer drug used was switched from famotidine, a H(2)-receptor antagonist, to omeprazole, a proton pump inhibitor, owing to the pharmacist’s intervention. METHODS: Hepatectomized recipients over 65 years of age, except in the cases of laparoscopic surgery and intensive care unit entry, were treated with famotidine injections (10 patients) or omeprazole injections (11 patients), and the incidence rates and severity of delirium were compared between the famotidine and omeprazole groups. The delirium after hepatectomy was assessed using the Japanese version of the NEECHAM confusion scale. RESULTS: The incidence rates of delirium were 90% in the famotidine group and 27.3% in the omeprazole group. Four out of 9 recipients in the famotidine group were injected with haloperidol to treat for delirium, but no recipients needed this treatment in the omeprazole group. CONCLUSIONS: Compared with famotidine, the use of omeprazole was found to be effective in reducing the incidence rate and severity of postoperative delirium in patients undergoing hepatectomy. Pharmacists should actively strive to mitigate the risks of delirium. BioMed Central 2019-05-07 /pmc/articles/PMC6505269/ /pubmed/31086675 http://dx.doi.org/10.1186/s40780-019-0139-1 Text en © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Yamasaki, Miho
Fukuda, Yusa
Tanimoto, Aika
Narahara, Miko
Kawaguchi, Yumi
Ushiroda, Hiromi
Fukuda, Saburo
Murakami, Teruo
Maeda, Yorinobu
Reduction in the rate of postoperative delirium by switching from famotidine to omeprazole in Japanese hepatectomized recipients
title Reduction in the rate of postoperative delirium by switching from famotidine to omeprazole in Japanese hepatectomized recipients
title_full Reduction in the rate of postoperative delirium by switching from famotidine to omeprazole in Japanese hepatectomized recipients
title_fullStr Reduction in the rate of postoperative delirium by switching from famotidine to omeprazole in Japanese hepatectomized recipients
title_full_unstemmed Reduction in the rate of postoperative delirium by switching from famotidine to omeprazole in Japanese hepatectomized recipients
title_short Reduction in the rate of postoperative delirium by switching from famotidine to omeprazole in Japanese hepatectomized recipients
title_sort reduction in the rate of postoperative delirium by switching from famotidine to omeprazole in japanese hepatectomized recipients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505269/
https://www.ncbi.nlm.nih.gov/pubmed/31086675
http://dx.doi.org/10.1186/s40780-019-0139-1
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