Cargando…

A disulphide bond in the E2 enzyme Pex4p modulates ubiquitin-conjugating activity

The ubiquitin-conjugating enzyme Pex4p together with its binding partner, the peroxisomal membrane protein Pex22p, co-ordinates cysteine-dependent ubiquitination of the cycling receptor protein Pex5p. Unusually for an ubiquitin-conjugating enzyme, Saccharomyces cerevisiae Pex4p can form a disulphide...

Descripción completa

Detalles Bibliográficos
Autores principales:	Williams, Chris, van den Berg, Marlene, Stanley, Will A., Wilmanns, Matthias, Distel, Ben
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505396/ https://www.ncbi.nlm.nih.gov/pubmed/23896733 http://dx.doi.org/10.1038/srep02212

Ejemplares similares

Pex22p of Pichia pastoris, Essential for Peroxisomal Matrix Protein Import, Anchors the Ubiquitin-Conjugating Enzyme, Pex4p, on the Peroxisomal Membrane
por: Koller, Antonius, et al.
Publicado: (1999)

Elevated growth temperature decreases levels of the PEX5 peroxisome-targeting signal receptor and ameliorates defects of Arabidopsis mutants with an impaired PEX4 ubiquitin-conjugating enzyme
por: Kao, Yun-Ting, et al.
Publicado: (2015)

PEX13 prevents pexophagy by regulating ubiquitinated PEX5 and peroxisomal ROS
por: Demers, Nicholas D., et al.
Publicado: (2023)

Ubiquitin-conjugating activity by PEX4 is required for efficient protein transport to peroxisomes in Arabidopsis thaliana
por: Mano, Shoji, et al.
Publicado: (2022)

The Structure of the Arabidopsis PEX4-PEX22 Peroxin Complex—Insights Into Ubiquitination at the Peroxisomal Membrane
por: Traver, Melissa S., et al.
Publicado: (2022)

DSDBASE 2.0: updated version of DiSulphide dataBASE, a database on disulphide bonds in proteins
por: Kalmankar, Neha V, et al.
Publicado: (2022)

PEX2 is the E3 ubiquitin ligase required for pexophagy during starvation
por: Sargent, Graeme, et al.
Publicado: (2016)

The Peroxisomal Targeting Signal 1 in sterol carrier protein 2 is autonomous and essential for receptor recognition
por: Williams, Chris P, et al.
Publicado: (2011)

PEX5 and Ubiquitin Dynamics on Mammalian Peroxisome Membranes
por: Brown, Aidan I., et al.
Publicado: (2014)

Ubiquitin-Conjugating Enzymes in Cancer
por: Bui, Quyen Thu, et al.
Publicado: (2021)

Role of Disulphide Bonds in Membrane Partitioning of a Viral Peptide
por: Sikdar, Samapan, et al.
Publicado: (2022)

The Cytosolic Domain of Pex22p Stimulates the Pex4p-Dependent Ubiquitination of the PTS1-Receptor
por: El Magraoui, Fouzi, et al.
Publicado: (2014)

Allosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX19
por: Emmanouilidis, Leonidas, et al.
Publicado: (2017)

An intramolecular disulphide bond in human 4E-T affects its binding to eIF4E1a protein
por: Zuberek, Joanna, et al.
Publicado: (2023)

A previously unobserved conformation for the human Pex5p receptor suggests roles for intrinsic flexibility and rigid domain motions in ligand binding
por: Stanley, Will A, et al.
Publicado: (2007)

Studies on the structure and immunological activity of carcinoembryonic antigen - the role of disulphide bonds.
por: Westwood, J. H., et al.
Publicado: (1975)

Structural insights into E1 recognition and the ubiquitin-conjugating activity of the E2 enzyme Cdc34
por: Williams, Katelyn M., et al.
Publicado: (2019)

Spectrum of PEX1 and PEX6 variants in Heimler syndrome
por: Smith, Claire E L, et al.
Publicado: (2016)

Phosphorylation of the receptor protein Pex5p modulates import of proteins into peroxisomes
por: Fischer, Sven, et al.
Publicado: (2023)

The Ubiquitin Conjugating Enzyme: An Important Ubiquitin Transfer Platform in Ubiquitin-Proteasome System
por: Liu, Weigang, et al.
Publicado: (2020)

Importance of disulphide bonds for vaccinia virus L1R protein function
por: Blouch, Robert E, et al.
Publicado: (2005)

Analysis on conservation of disulphide bonds and their structural features in homologous protein domain families
por: Thangudu, Ratna R, et al.
Publicado: (2008)

Controlling the dynamics of the Nek2 leucine zipper by engineering of “kinetic” disulphide bonds
por: Gutmans, Daniel S., et al.
Publicado: (2019)

E2 ubiquitin conjugating enzymes regulate the deubiquitinating activity of OTUB1
por: Wiener, Reuven, et al.
Publicado: (2013)

Expression of ubiquitin-conjugating enzyme E2T in colorectal cancers and clinical implications
por: Wu, Xiangtian, et al.
Publicado: (2020)

Intraoperative Dilemmas in Polyorchidism: To Pex or not to Pex!!
por: Mittal, Priyanka Garg, et al.
Publicado: (2020)

The Pex6 N1 domain is required for Pex15 binding and proper assembly with Pex1
por: Ali, Bashir A., et al.
Publicado: (2023)

Wheat germ-based protein libraries for the functional characterisation of the Arabidopsis E2 ubiquitin conjugating enzymes and the RING-type E3 ubiquitin ligase enzymes
por: Ramadan, Abdelaziz, et al.
Publicado: (2015)

Ubiquitination of the peroxisomal import receptor Pex5p is required for its recycling
por: Platta, Harald W., et al.
Publicado: (2007)

Mutations of Rad6 E2 ubiquitin-conjugating enzymes at alanine-126 in helix-3 affect ubiquitination activity and decrease enzyme stability
por: Shukla, Prakash K., et al.
Publicado: (2022)

Evaluation of irreversible protein thermal inactivation caused by breakage of disulphide bonds using methanethiosulphonate
por: Futami, Junichiro, et al.
Publicado: (2017)

Loss of the ubiquitin conjugating enzyme UBE2E3 induces cellular senescence
por: Plafker, Kendra S., et al.
Publicado: (2018)

Genome-wide identification and expression analysis of E2 ubiquitin-conjugating enzymes in tomato
por: Sharma, Bhaskar, et al.
Publicado: (2017)

Targeting CDC34 E2 ubiquitin conjugating enzyme for lung cancer therapy
por: Zhang, Shizhen, et al.
Publicado: (2020)

Interactions between the quality control ubiquitin ligase CHIP and ubiquitin conjugating enzymes
por: Xu, Zhen, et al.
Publicado: (2008)

What Was the Set of Ubiquitin and Ubiquitin-Like Conjugating Enzymes in the Eukaryote Common Ancestor?
por: Michelle, Caroline, et al.
Publicado: (2009)

Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans: ubiquitin-conjugating enzymes, ubiquitin-activating enzymes, and ubiquitin-like proteins
por: Jones, Donald, et al.
Publicado: (2002)

Ubiquitin conjugating enzymes participate in polyglutamine protein aggregation
por: Howard, Rebecca A, et al.
Publicado: (2007)

The Acid Soluble Disulphide and Mixed Disulphide Levels of Some Normal Tissues and Transplanted Tumours
por: Calcutt, G., et al.
Publicado: (1970)

A non-catalytic disulphide bond regulating redox flux in the ER oxidative folding pathway
por: Freedman, Robert B
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_4bqokprsoe1jvpnp0t4besep0s