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Pyoderma Gangrenosum in the Absence of Any Underlying Predisposing Condition: A Diagnostic Dilemma

Pyoderma gangrenosum (PG) is a rare non-infectious skin disease of undetermined origin. It is characterized by a single or multiple painful, necrotic ulcers. Formerly, PG was assumed to be infectious, but eventually, it was established to be an inflammatory disorder that is commonly associated with...

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Autores principales: Jain, Akriti G, Sharbatji, Mohamad, Afzal, Ali, Afridi, Summia Matin, Gordon, Dwayne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505723/
https://www.ncbi.nlm.nih.gov/pubmed/31114732
http://dx.doi.org/10.7759/cureus.4213
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author Jain, Akriti G
Sharbatji, Mohamad
Afzal, Ali
Afridi, Summia Matin
Gordon, Dwayne
author_facet Jain, Akriti G
Sharbatji, Mohamad
Afzal, Ali
Afridi, Summia Matin
Gordon, Dwayne
author_sort Jain, Akriti G
collection PubMed
description Pyoderma gangrenosum (PG) is a rare non-infectious skin disease of undetermined origin. It is characterized by a single or multiple painful, necrotic ulcers. Formerly, PG was assumed to be infectious, but eventually, it was established to be an inflammatory disorder that is commonly associated with autoimmune and neoplastic diseases. We report a case of PG in a 70-year-old female who presented on the pretibial area as a single non-healing ulcer. It started as a small induration that worsened over the course of two weeks despite being on antibiotics. We started the patient on corticosteroids and high potency topical steroids that resulted in healing of the ulcer. PG can prove to be a diagnostic dilemma and can be inappropriately treated with antibiotics or even something radical like an amputation if misdiagnosed. Hence, physicians need to think of this entity even in the absence of any predisposing conditions.
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spelling pubmed-65057232019-05-21 Pyoderma Gangrenosum in the Absence of Any Underlying Predisposing Condition: A Diagnostic Dilemma Jain, Akriti G Sharbatji, Mohamad Afzal, Ali Afridi, Summia Matin Gordon, Dwayne Cureus Allergy/Immunology Pyoderma gangrenosum (PG) is a rare non-infectious skin disease of undetermined origin. It is characterized by a single or multiple painful, necrotic ulcers. Formerly, PG was assumed to be infectious, but eventually, it was established to be an inflammatory disorder that is commonly associated with autoimmune and neoplastic diseases. We report a case of PG in a 70-year-old female who presented on the pretibial area as a single non-healing ulcer. It started as a small induration that worsened over the course of two weeks despite being on antibiotics. We started the patient on corticosteroids and high potency topical steroids that resulted in healing of the ulcer. PG can prove to be a diagnostic dilemma and can be inappropriately treated with antibiotics or even something radical like an amputation if misdiagnosed. Hence, physicians need to think of this entity even in the absence of any predisposing conditions. Cureus 2019-03-09 /pmc/articles/PMC6505723/ /pubmed/31114732 http://dx.doi.org/10.7759/cureus.4213 Text en Copyright © 2019, Jain et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Allergy/Immunology
Jain, Akriti G
Sharbatji, Mohamad
Afzal, Ali
Afridi, Summia Matin
Gordon, Dwayne
Pyoderma Gangrenosum in the Absence of Any Underlying Predisposing Condition: A Diagnostic Dilemma
title Pyoderma Gangrenosum in the Absence of Any Underlying Predisposing Condition: A Diagnostic Dilemma
title_full Pyoderma Gangrenosum in the Absence of Any Underlying Predisposing Condition: A Diagnostic Dilemma
title_fullStr Pyoderma Gangrenosum in the Absence of Any Underlying Predisposing Condition: A Diagnostic Dilemma
title_full_unstemmed Pyoderma Gangrenosum in the Absence of Any Underlying Predisposing Condition: A Diagnostic Dilemma
title_short Pyoderma Gangrenosum in the Absence of Any Underlying Predisposing Condition: A Diagnostic Dilemma
title_sort pyoderma gangrenosum in the absence of any underlying predisposing condition: a diagnostic dilemma
topic Allergy/Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505723/
https://www.ncbi.nlm.nih.gov/pubmed/31114732
http://dx.doi.org/10.7759/cureus.4213
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