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DNA polymerase η modulates replication fork progression and DNA damage responses in platinum-treated human cells

Human cells lacking DNA polymerase η (polη) are sensitive to platinum-based cancer chemotherapeutic agents. Using DNA combing to directly investigate the role of polη in bypass of platinum-induced DNA lesions in vivo, we demonstrate that nascent DNA strands are up to 39% shorter in human cells lacki...

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Detalles Bibliográficos
Autores principales:	Sokol, Anna M., Cruet-Hennequart, Séverine, Pasero, Philippe, Carty, Michael P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505966/ https://www.ncbi.nlm.nih.gov/pubmed/24253929 http://dx.doi.org/10.1038/srep03277

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