Diagonal Earlobe Crease, a Marker of Coronary Artery Disease: A Case Report on Frank's Sign

There are various physical signs that can be used as a reliable tool to diagnose the subclinical stages of atherosclerosis, including corneal arcus, xanthelasma, and diagonal earlobe crease (DELC) or “Frank's sign”. Bilateral diagonal earlobe crease has been positively correlated with coronary...

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Detalles Bibliográficos
Autores principales: Baboujian, Araz, Bezwada, Prema, Ayala-Rodriguez, Cesar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2019
Materias:
Cardiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506272/
https://www.ncbi.nlm.nih.gov/pubmed/31106102
http://dx.doi.org/10.7759/cureus.4219
Descripción
Sumario:There are various physical signs that can be used as a reliable tool to diagnose the subclinical stages of atherosclerosis, including corneal arcus, xanthelasma, and diagonal earlobe crease (DELC) or “Frank's sign”. Bilateral diagonal earlobe crease has been positively correlated with coronary artery disease (CAD) and peripheral vascular disease (PVD). The presence of DELC has been identified as an independent variable for CAD. The exact etiology is unknown and the association between the presence of DELC and coronary artery disease (CAD) still remains controversial. We report a case of a patient with bilateral DELC who was found to have remarkable non-occlusive CAD on diagnostic coronary angiography.

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