Diagonal Earlobe Crease, a Marker of Coronary Artery Disease: A Case Report on Frank's Sign

There are various physical signs that can be used as a reliable tool to diagnose the subclinical stages of atherosclerosis, including corneal arcus, xanthelasma, and diagonal earlobe crease (DELC) or “Frank's sign”. Bilateral diagonal earlobe crease has been positively correlated with coronary...

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Detalles Bibliográficos
Autores principales: Baboujian, Araz, Bezwada, Prema, Ayala-Rodriguez, Cesar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2019
Materias:
Cardiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506272/
https://www.ncbi.nlm.nih.gov/pubmed/31106102
http://dx.doi.org/10.7759/cureus.4219
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author Baboujian, Araz
Bezwada, Prema
Ayala-Rodriguez, Cesar
author_facet Baboujian, Araz
Bezwada, Prema
Ayala-Rodriguez, Cesar
author_sort Baboujian, Araz
collection PubMed
description There are various physical signs that can be used as a reliable tool to diagnose the subclinical stages of atherosclerosis, including corneal arcus, xanthelasma, and diagonal earlobe crease (DELC) or “Frank's sign”. Bilateral diagonal earlobe crease has been positively correlated with coronary artery disease (CAD) and peripheral vascular disease (PVD). The presence of DELC has been identified as an independent variable for CAD. The exact etiology is unknown and the association between the presence of DELC and coronary artery disease (CAD) still remains controversial. We report a case of a patient with bilateral DELC who was found to have remarkable non-occlusive CAD on diagnostic coronary angiography.
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spelling pubmed-65062722019-05-18 Diagonal Earlobe Crease, a Marker of Coronary Artery Disease: A Case Report on Frank's Sign Baboujian, Araz Bezwada, Prema Ayala-Rodriguez, Cesar Cureus Cardiology There are various physical signs that can be used as a reliable tool to diagnose the subclinical stages of atherosclerosis, including corneal arcus, xanthelasma, and diagonal earlobe crease (DELC) or “Frank's sign”. Bilateral diagonal earlobe crease has been positively correlated with coronary artery disease (CAD) and peripheral vascular disease (PVD). The presence of DELC has been identified as an independent variable for CAD. The exact etiology is unknown and the association between the presence of DELC and coronary artery disease (CAD) still remains controversial. We report a case of a patient with bilateral DELC who was found to have remarkable non-occlusive CAD on diagnostic coronary angiography. Cureus 2019-03-11 /pmc/articles/PMC6506272/ /pubmed/31106102 http://dx.doi.org/10.7759/cureus.4219 Text en Copyright © 2019, Baboujian et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Cardiology
Baboujian, Araz
Bezwada, Prema
Ayala-Rodriguez, Cesar
Diagonal Earlobe Crease, a Marker of Coronary Artery Disease: A Case Report on Frank's Sign
title Diagonal Earlobe Crease, a Marker of Coronary Artery Disease: A Case Report on Frank's Sign
title_full Diagonal Earlobe Crease, a Marker of Coronary Artery Disease: A Case Report on Frank's Sign
title_fullStr Diagonal Earlobe Crease, a Marker of Coronary Artery Disease: A Case Report on Frank's Sign
title_full_unstemmed Diagonal Earlobe Crease, a Marker of Coronary Artery Disease: A Case Report on Frank's Sign
title_short Diagonal Earlobe Crease, a Marker of Coronary Artery Disease: A Case Report on Frank's Sign
title_sort diagonal earlobe crease, a marker of coronary artery disease: a case report on frank's sign
topic Cardiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506272/
https://www.ncbi.nlm.nih.gov/pubmed/31106102
http://dx.doi.org/10.7759/cureus.4219
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AT ayalarodriguezcesar diagonalearlobecreaseamarkerofcoronaryarterydiseaseacasereportonfrankssign

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