Promoter-Intrinsic and Local Chromatin Features Determine Gene Repression in LADs

It is largely unclear whether genes that are naturally embedded in lamina-associated domains (LADs) are inactive due to their chromatin environment or whether LADs are merely secondary to the lack of transcription. We show that hundreds of human promoters become active when moved from their native L...

Descripción completa

Detalles Bibliográficos
Autores principales: Leemans, Christ, van der Zwalm, Marloes C.H., Brueckner, Laura, Comoglio, Federico, van Schaik, Tom, Pagie, Ludo, van Arensbergen, Joris, van Steensel, Bas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506275/
https://www.ncbi.nlm.nih.gov/pubmed/30982597
http://dx.doi.org/10.1016/j.cell.2019.03.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506275/
https://www.ncbi.nlm.nih.gov/pubmed/30982597
http://dx.doi.org/10.1016/j.cell.2019.03.009

Ejemplares similares