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Promoter-Intrinsic and Local Chromatin Features Determine Gene Repression in LADs
It is largely unclear whether genes that are naturally embedded in lamina-associated domains (LADs) are inactive due to their chromatin environment or whether LADs are merely secondary to the lack of transcription. We show that hundreds of human promoters become active when moved from their native L...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506275/ https://www.ncbi.nlm.nih.gov/pubmed/30982597 http://dx.doi.org/10.1016/j.cell.2019.03.009 |