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Insulin/IGF-1 Drives PERIOD Synthesis to Entrain Circadian Rhythms with Feeding Time

In mammals, endogenous circadian clocks sense and respond to daily feeding and lighting cues, adjusting internal ∼24 h rhythms to resonate with, and anticipate, external cycles of day and night. The mechanism underlying circadian entrainment to feeding time is critical for understanding why mistimed...

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Autores principales: Crosby, Priya, Hamnett, Ryan, Putker, Marrit, Hoyle, Nathaniel P., Reed, Martin, Karam, Carolyn J., Maywood, Elizabeth S., Stangherlin, Alessandra, Chesham, Johanna E., Hayter, Edward A., Rosenbrier-Ribeiro, Lyn, Newham, Peter, Clevers, Hans, Bechtold, David A., O’Neill, John S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506277/
https://www.ncbi.nlm.nih.gov/pubmed/31030999
http://dx.doi.org/10.1016/j.cell.2019.02.017
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author Crosby, Priya
Hamnett, Ryan
Putker, Marrit
Hoyle, Nathaniel P.
Reed, Martin
Karam, Carolyn J.
Maywood, Elizabeth S.
Stangherlin, Alessandra
Chesham, Johanna E.
Hayter, Edward A.
Rosenbrier-Ribeiro, Lyn
Newham, Peter
Clevers, Hans
Bechtold, David A.
O’Neill, John S.
author_facet Crosby, Priya
Hamnett, Ryan
Putker, Marrit
Hoyle, Nathaniel P.
Reed, Martin
Karam, Carolyn J.
Maywood, Elizabeth S.
Stangherlin, Alessandra
Chesham, Johanna E.
Hayter, Edward A.
Rosenbrier-Ribeiro, Lyn
Newham, Peter
Clevers, Hans
Bechtold, David A.
O’Neill, John S.
author_sort Crosby, Priya
collection PubMed
description In mammals, endogenous circadian clocks sense and respond to daily feeding and lighting cues, adjusting internal ∼24 h rhythms to resonate with, and anticipate, external cycles of day and night. The mechanism underlying circadian entrainment to feeding time is critical for understanding why mistimed feeding, as occurs during shift work, disrupts circadian physiology, a state that is associated with increased incidence of chronic diseases such as type 2 (T2) diabetes. We show that feeding-regulated hormones insulin and insulin-like growth factor 1 (IGF-1) reset circadian clocks in vivo and in vitro by induction of PERIOD proteins, and mistimed insulin signaling disrupts circadian organization of mouse behavior and clock gene expression. Insulin and IGF-1 receptor signaling is sufficient to determine essential circadian parameters, principally via increased PERIOD protein synthesis. This requires coincident mechanistic target of rapamycin (mTOR) activation, increased phosphoinositide signaling, and microRNA downregulation. Besides its well-known homeostatic functions, we propose insulin and IGF-1 are primary signals of feeding time to cellular clocks throughout the body.
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spelling pubmed-65062772019-05-13 Insulin/IGF-1 Drives PERIOD Synthesis to Entrain Circadian Rhythms with Feeding Time Crosby, Priya Hamnett, Ryan Putker, Marrit Hoyle, Nathaniel P. Reed, Martin Karam, Carolyn J. Maywood, Elizabeth S. Stangherlin, Alessandra Chesham, Johanna E. Hayter, Edward A. Rosenbrier-Ribeiro, Lyn Newham, Peter Clevers, Hans Bechtold, David A. O’Neill, John S. Cell Article In mammals, endogenous circadian clocks sense and respond to daily feeding and lighting cues, adjusting internal ∼24 h rhythms to resonate with, and anticipate, external cycles of day and night. The mechanism underlying circadian entrainment to feeding time is critical for understanding why mistimed feeding, as occurs during shift work, disrupts circadian physiology, a state that is associated with increased incidence of chronic diseases such as type 2 (T2) diabetes. We show that feeding-regulated hormones insulin and insulin-like growth factor 1 (IGF-1) reset circadian clocks in vivo and in vitro by induction of PERIOD proteins, and mistimed insulin signaling disrupts circadian organization of mouse behavior and clock gene expression. Insulin and IGF-1 receptor signaling is sufficient to determine essential circadian parameters, principally via increased PERIOD protein synthesis. This requires coincident mechanistic target of rapamycin (mTOR) activation, increased phosphoinositide signaling, and microRNA downregulation. Besides its well-known homeostatic functions, we propose insulin and IGF-1 are primary signals of feeding time to cellular clocks throughout the body. Cell Press 2019-05-02 /pmc/articles/PMC6506277/ /pubmed/31030999 http://dx.doi.org/10.1016/j.cell.2019.02.017 Text en © 2019 MRC Laboratory of Molecular Biology http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Crosby, Priya
Hamnett, Ryan
Putker, Marrit
Hoyle, Nathaniel P.
Reed, Martin
Karam, Carolyn J.
Maywood, Elizabeth S.
Stangherlin, Alessandra
Chesham, Johanna E.
Hayter, Edward A.
Rosenbrier-Ribeiro, Lyn
Newham, Peter
Clevers, Hans
Bechtold, David A.
O’Neill, John S.
Insulin/IGF-1 Drives PERIOD Synthesis to Entrain Circadian Rhythms with Feeding Time
title Insulin/IGF-1 Drives PERIOD Synthesis to Entrain Circadian Rhythms with Feeding Time
title_full Insulin/IGF-1 Drives PERIOD Synthesis to Entrain Circadian Rhythms with Feeding Time
title_fullStr Insulin/IGF-1 Drives PERIOD Synthesis to Entrain Circadian Rhythms with Feeding Time
title_full_unstemmed Insulin/IGF-1 Drives PERIOD Synthesis to Entrain Circadian Rhythms with Feeding Time
title_short Insulin/IGF-1 Drives PERIOD Synthesis to Entrain Circadian Rhythms with Feeding Time
title_sort insulin/igf-1 drives period synthesis to entrain circadian rhythms with feeding time
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506277/
https://www.ncbi.nlm.nih.gov/pubmed/31030999
http://dx.doi.org/10.1016/j.cell.2019.02.017
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