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Histopathological effects of modern topical sealants on the liver surface after hepatectomy: an experimental swine study
The present study aimed to determine the impact of different sealant materials on histopathological changes to the liver surface after liver resection. Thirty-six landrace pigs underwent left anatomical hemihepatectomy and were assigned to a histopathological control group (HPC, n = 9) with no bleed...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506469/ https://www.ncbi.nlm.nih.gov/pubmed/31068637 http://dx.doi.org/10.1038/s41598-019-43694-6 |
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author | Fonouni, Hamidreza Khajeh, Elias Ghamarnejad, Omid Kashfi, Arash Aydogdu, Emre Majlesara, Ali Mohammadi, Sara Gharabaghi, Negin Konstantinidis, Lukas Longerich, Thomas Mehrabi, Arianeb Kulu, Yakup |
author_facet | Fonouni, Hamidreza Khajeh, Elias Ghamarnejad, Omid Kashfi, Arash Aydogdu, Emre Majlesara, Ali Mohammadi, Sara Gharabaghi, Negin Konstantinidis, Lukas Longerich, Thomas Mehrabi, Arianeb Kulu, Yakup |
author_sort | Fonouni, Hamidreza |
collection | PubMed |
description | The present study aimed to determine the impact of different sealant materials on histopathological changes to the liver surface after liver resection. Thirty-six landrace pigs underwent left anatomical hemihepatectomy and were assigned to a histopathological control group (HPC, n = 9) with no bleeding control, a clinically simulated control group (CSC, n = 9) with no sealant but bipolar cauterization and oversewing of the liver surface, and two treatment groups (n = 9 each) with a collagen-based sealant (CBS) or a fibrinogen-based sealant (FBS) on resection surface. After postoperative day 6, tissue samples were histologically examined. There were no significant differences in preoperative parameters between the groups. Fibrin production was higher in sealant groups compared with the HPC and CSC groups (both p < 0.001). Hepatocellular regeneration in sealant groups was higher than in both control groups. A significantly higher regeneration was seen in the FBS group. Use of sealants increased the degree of fibrin exudation at the resection plane. Increased hepatocellular necrosis was seen in the CBS group compared with the FBS group. The posthepatectomy hepatocellular regeneration rate was higher in the FBS group compared with the CBS group. Randomized studies are needed to assess the impact of sealants on posthepatectomy liver regeneration in the clinical setting. |
format | Online Article Text |
id | pubmed-6506469 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-65064692019-05-21 Histopathological effects of modern topical sealants on the liver surface after hepatectomy: an experimental swine study Fonouni, Hamidreza Khajeh, Elias Ghamarnejad, Omid Kashfi, Arash Aydogdu, Emre Majlesara, Ali Mohammadi, Sara Gharabaghi, Negin Konstantinidis, Lukas Longerich, Thomas Mehrabi, Arianeb Kulu, Yakup Sci Rep Article The present study aimed to determine the impact of different sealant materials on histopathological changes to the liver surface after liver resection. Thirty-six landrace pigs underwent left anatomical hemihepatectomy and were assigned to a histopathological control group (HPC, n = 9) with no bleeding control, a clinically simulated control group (CSC, n = 9) with no sealant but bipolar cauterization and oversewing of the liver surface, and two treatment groups (n = 9 each) with a collagen-based sealant (CBS) or a fibrinogen-based sealant (FBS) on resection surface. After postoperative day 6, tissue samples were histologically examined. There were no significant differences in preoperative parameters between the groups. Fibrin production was higher in sealant groups compared with the HPC and CSC groups (both p < 0.001). Hepatocellular regeneration in sealant groups was higher than in both control groups. A significantly higher regeneration was seen in the FBS group. Use of sealants increased the degree of fibrin exudation at the resection plane. Increased hepatocellular necrosis was seen in the CBS group compared with the FBS group. The posthepatectomy hepatocellular regeneration rate was higher in the FBS group compared with the CBS group. Randomized studies are needed to assess the impact of sealants on posthepatectomy liver regeneration in the clinical setting. Nature Publishing Group UK 2019-05-08 /pmc/articles/PMC6506469/ /pubmed/31068637 http://dx.doi.org/10.1038/s41598-019-43694-6 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Fonouni, Hamidreza Khajeh, Elias Ghamarnejad, Omid Kashfi, Arash Aydogdu, Emre Majlesara, Ali Mohammadi, Sara Gharabaghi, Negin Konstantinidis, Lukas Longerich, Thomas Mehrabi, Arianeb Kulu, Yakup Histopathological effects of modern topical sealants on the liver surface after hepatectomy: an experimental swine study |
title | Histopathological effects of modern topical sealants on the liver surface after hepatectomy: an experimental swine study |
title_full | Histopathological effects of modern topical sealants on the liver surface after hepatectomy: an experimental swine study |
title_fullStr | Histopathological effects of modern topical sealants on the liver surface after hepatectomy: an experimental swine study |
title_full_unstemmed | Histopathological effects of modern topical sealants on the liver surface after hepatectomy: an experimental swine study |
title_short | Histopathological effects of modern topical sealants on the liver surface after hepatectomy: an experimental swine study |
title_sort | histopathological effects of modern topical sealants on the liver surface after hepatectomy: an experimental swine study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506469/ https://www.ncbi.nlm.nih.gov/pubmed/31068637 http://dx.doi.org/10.1038/s41598-019-43694-6 |
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