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The Rho/MRTF pathway inhibitor CCG-222740 reduces stellate cell activation and modulates immune cell populations in Kras(G12D); Pdx1-Cre (KC) mice

The stromal reaction in pancreatic cancer creates a physical barrier that blocks therapeutic intervention and creates an immunosuppressive tumor microenvironment. The Rho/myocardin-related transcription factor (MRTF) pathway is implicated in the hyper-activation of fibroblasts in fibrotic diseases a...

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Detalles Bibliográficos
Autores principales:	Leal, Ana S., Misek, Sean A., Lisabeth, Erika M., Neubig, Richard R., Liby, Karen T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506531/ https://www.ncbi.nlm.nih.gov/pubmed/31068602 http://dx.doi.org/10.1038/s41598-019-43430-0

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