Mediastinal cryptococcosis simulating thyroid neoplasia in immunocompetent patient with prior diagnosis and treatment for COPD

We report a case of mediastinal cryptococcosis with thyroid invasion in a patient who presented dry cough and persistent dyspnea. This patient has been treated for COPD, presenting no clinical responses. Spirometry showed fixed flattening of inspiratory and expiratory loops, suggesting extrinsic tra...

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Autores principales: Dias Lopes, Mariana Registro, Röper, Gabriel Belincanta, Dias Lopes, Francisco Antonio, Moreira Neto, Luiz Jorge, Svidzinski, Terezinha Inez Estivalet, Grava, Sergio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506561/
https://www.ncbi.nlm.nih.gov/pubmed/31080717
http://dx.doi.org/10.1016/j.mmcr.2019.04.008
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author Dias Lopes, Mariana Registro
Röper, Gabriel Belincanta
Dias Lopes, Francisco Antonio
Moreira Neto, Luiz Jorge
Svidzinski, Terezinha Inez Estivalet
Grava, Sergio
author_facet Dias Lopes, Mariana Registro
Röper, Gabriel Belincanta
Dias Lopes, Francisco Antonio
Moreira Neto, Luiz Jorge
Svidzinski, Terezinha Inez Estivalet
Grava, Sergio
author_sort Dias Lopes, Mariana Registro
collection PubMed
description We report a case of mediastinal cryptococcosis with thyroid invasion in a patient who presented dry cough and persistent dyspnea. This patient has been treated for COPD, presenting no clinical responses. Spirometry showed fixed flattening of inspiratory and expiratory loops, suggesting extrinsic tracheal compression. A freezing biopsy revealed a mass consisting of lymph nodes and yeasts with characteristics of Cryptococcus spp. After surgical resection of the lesion, the patient was treated with fluconazole, showing total remission of the disease and symptomatology.
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spelling pubmed-65065612019-05-10 Mediastinal cryptococcosis simulating thyroid neoplasia in immunocompetent patient with prior diagnosis and treatment for COPD Dias Lopes, Mariana Registro Röper, Gabriel Belincanta Dias Lopes, Francisco Antonio Moreira Neto, Luiz Jorge Svidzinski, Terezinha Inez Estivalet Grava, Sergio Med Mycol Case Rep Case Report We report a case of mediastinal cryptococcosis with thyroid invasion in a patient who presented dry cough and persistent dyspnea. This patient has been treated for COPD, presenting no clinical responses. Spirometry showed fixed flattening of inspiratory and expiratory loops, suggesting extrinsic tracheal compression. A freezing biopsy revealed a mass consisting of lymph nodes and yeasts with characteristics of Cryptococcus spp. After surgical resection of the lesion, the patient was treated with fluconazole, showing total remission of the disease and symptomatology. Elsevier 2019-04-27 /pmc/articles/PMC6506561/ /pubmed/31080717 http://dx.doi.org/10.1016/j.mmcr.2019.04.008 Text en © 2019 The Authors. Published by Elsevier B.V. on behalf of International Society for Human and Animal Mycology. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Dias Lopes, Mariana Registro
Röper, Gabriel Belincanta
Dias Lopes, Francisco Antonio
Moreira Neto, Luiz Jorge
Svidzinski, Terezinha Inez Estivalet
Grava, Sergio
Mediastinal cryptococcosis simulating thyroid neoplasia in immunocompetent patient with prior diagnosis and treatment for COPD
title Mediastinal cryptococcosis simulating thyroid neoplasia in immunocompetent patient with prior diagnosis and treatment for COPD
title_full Mediastinal cryptococcosis simulating thyroid neoplasia in immunocompetent patient with prior diagnosis and treatment for COPD
title_fullStr Mediastinal cryptococcosis simulating thyroid neoplasia in immunocompetent patient with prior diagnosis and treatment for COPD
title_full_unstemmed Mediastinal cryptococcosis simulating thyroid neoplasia in immunocompetent patient with prior diagnosis and treatment for COPD
title_short Mediastinal cryptococcosis simulating thyroid neoplasia in immunocompetent patient with prior diagnosis and treatment for COPD
title_sort mediastinal cryptococcosis simulating thyroid neoplasia in immunocompetent patient with prior diagnosis and treatment for copd
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506561/
https://www.ncbi.nlm.nih.gov/pubmed/31080717
http://dx.doi.org/10.1016/j.mmcr.2019.04.008
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