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Platelet function in HIV plus dengue coinfection associates with reduced inflammation and milder dengue illness

HIV-infected subjects under virological control still exhibit a persistent proinflammatory state. Thus, chronic HIV infection changes the host homeostasis towards an adapted immune response that may affect the outcome of coinfections. However, little is known about the impact of HIV infection on inf...

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Autores principales: Hottz, Eugenio D., Quirino-Teixeira, Anna Cecíllia, Valls-de-Souza, Rogério, Zimmerman, Guy A., Bozza, Fernando A., Bozza, Patrícia T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506591/
https://www.ncbi.nlm.nih.gov/pubmed/31068600
http://dx.doi.org/10.1038/s41598-019-43275-7
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author Hottz, Eugenio D.
Quirino-Teixeira, Anna Cecíllia
Valls-de-Souza, Rogério
Zimmerman, Guy A.
Bozza, Fernando A.
Bozza, Patrícia T.
author_facet Hottz, Eugenio D.
Quirino-Teixeira, Anna Cecíllia
Valls-de-Souza, Rogério
Zimmerman, Guy A.
Bozza, Fernando A.
Bozza, Patrícia T.
author_sort Hottz, Eugenio D.
collection PubMed
description HIV-infected subjects under virological control still exhibit a persistent proinflammatory state. Thus, chronic HIV infection changes the host homeostasis towards an adapted immune response that may affect the outcome of coinfections. However, little is known about the impact of HIV infection on inflammatory amplification and clinical presentation in dengue. Platelets have been shown to participate in immune response in dengue and HIV. We hypothesized that altered platelet responses in HIV-infected subjects may contribute to altered inflammatory milieu and disease progression in dengue. We prospectively followed a cohort of 84 DENV-infected patients of whom 29 were coinfected with HIV under virological control. We report that dengue and HIV coinfection progress with reduced inflammation and milder disease progression with lower risk of vascular instability. Even though the degree of thrombocytopenia and platelet activation were similar between dengue-infected and HIV plus dengue-coinfected patients, plasma levels of the platelet-derived chemokines RANTES/CCL5 and PF4/CXCL4 were lower in coinfection. Consistently, platelets from coinfected patients presented defective secretion of the stored-chemokines PF4 and RANTES, but not newly synthesized IL-1β, when cultured ex vivo. These data indicate that platelets from HIV-infected subjects release lower levels of chemokines during dengue illness, which may contribute to milder clinical presentation during coinfection.
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spelling pubmed-65065912019-05-21 Platelet function in HIV plus dengue coinfection associates with reduced inflammation and milder dengue illness Hottz, Eugenio D. Quirino-Teixeira, Anna Cecíllia Valls-de-Souza, Rogério Zimmerman, Guy A. Bozza, Fernando A. Bozza, Patrícia T. Sci Rep Article HIV-infected subjects under virological control still exhibit a persistent proinflammatory state. Thus, chronic HIV infection changes the host homeostasis towards an adapted immune response that may affect the outcome of coinfections. However, little is known about the impact of HIV infection on inflammatory amplification and clinical presentation in dengue. Platelets have been shown to participate in immune response in dengue and HIV. We hypothesized that altered platelet responses in HIV-infected subjects may contribute to altered inflammatory milieu and disease progression in dengue. We prospectively followed a cohort of 84 DENV-infected patients of whom 29 were coinfected with HIV under virological control. We report that dengue and HIV coinfection progress with reduced inflammation and milder disease progression with lower risk of vascular instability. Even though the degree of thrombocytopenia and platelet activation were similar between dengue-infected and HIV plus dengue-coinfected patients, plasma levels of the platelet-derived chemokines RANTES/CCL5 and PF4/CXCL4 were lower in coinfection. Consistently, platelets from coinfected patients presented defective secretion of the stored-chemokines PF4 and RANTES, but not newly synthesized IL-1β, when cultured ex vivo. These data indicate that platelets from HIV-infected subjects release lower levels of chemokines during dengue illness, which may contribute to milder clinical presentation during coinfection. Nature Publishing Group UK 2019-05-08 /pmc/articles/PMC6506591/ /pubmed/31068600 http://dx.doi.org/10.1038/s41598-019-43275-7 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Hottz, Eugenio D.
Quirino-Teixeira, Anna Cecíllia
Valls-de-Souza, Rogério
Zimmerman, Guy A.
Bozza, Fernando A.
Bozza, Patrícia T.
Platelet function in HIV plus dengue coinfection associates with reduced inflammation and milder dengue illness
title Platelet function in HIV plus dengue coinfection associates with reduced inflammation and milder dengue illness
title_full Platelet function in HIV plus dengue coinfection associates with reduced inflammation and milder dengue illness
title_fullStr Platelet function in HIV plus dengue coinfection associates with reduced inflammation and milder dengue illness
title_full_unstemmed Platelet function in HIV plus dengue coinfection associates with reduced inflammation and milder dengue illness
title_short Platelet function in HIV plus dengue coinfection associates with reduced inflammation and milder dengue illness
title_sort platelet function in hiv plus dengue coinfection associates with reduced inflammation and milder dengue illness
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506591/
https://www.ncbi.nlm.nih.gov/pubmed/31068600
http://dx.doi.org/10.1038/s41598-019-43275-7
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