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Proteomics insights into the pathology and prognosis of chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) is an incurable malignant disease of B-lymphocytes characterized by drastically heterogeneous clinical courses. Proteomics is an advanced approach that allows a global profiling of protein expression, providing a valuable chance for the discovery of disease-related...

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Detalles Bibliográficos
Autores principales: Alsagaby, Suliman A., Alhumaydhi, Fahad A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Saudi Medical Journal 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506661/
https://www.ncbi.nlm.nih.gov/pubmed/30957124
http://dx.doi.org/10.15537/smj.2019.4.23598
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author Alsagaby, Suliman A.
Alhumaydhi, Fahad A.
author_facet Alsagaby, Suliman A.
Alhumaydhi, Fahad A.
author_sort Alsagaby, Suliman A.
collection PubMed
description Chronic lymphocytic leukemia (CLL) is an incurable malignant disease of B-lymphocytes characterized by drastically heterogeneous clinical courses. Proteomics is an advanced approach that allows a global profiling of protein expression, providing a valuable chance for the discovery of disease-related proteins. In the last 2 decades, several proteomics studies were conducted on CLL to identify aberrant protein expression underpinning the malignant transformation and progression of the disease. Overall, these studies provided insights into the pathology and prognosis of CLL and reveal protein candidates with the potential to serve as biomarkers and/or therapeutic targets of the tumor. The major findings reported in these studies are discussed here.
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spelling pubmed-65066612019-05-22 Proteomics insights into the pathology and prognosis of chronic lymphocytic leukemia Alsagaby, Suliman A. Alhumaydhi, Fahad A. Saudi Med J Review Article Chronic lymphocytic leukemia (CLL) is an incurable malignant disease of B-lymphocytes characterized by drastically heterogeneous clinical courses. Proteomics is an advanced approach that allows a global profiling of protein expression, providing a valuable chance for the discovery of disease-related proteins. In the last 2 decades, several proteomics studies were conducted on CLL to identify aberrant protein expression underpinning the malignant transformation and progression of the disease. Overall, these studies provided insights into the pathology and prognosis of CLL and reveal protein candidates with the potential to serve as biomarkers and/or therapeutic targets of the tumor. The major findings reported in these studies are discussed here. Saudi Medical Journal 2019 /pmc/articles/PMC6506661/ /pubmed/30957124 http://dx.doi.org/10.15537/smj.2019.4.23598 Text en Copyright: © Saudi Medical Journal http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Alsagaby, Suliman A.
Alhumaydhi, Fahad A.
Proteomics insights into the pathology and prognosis of chronic lymphocytic leukemia
title Proteomics insights into the pathology and prognosis of chronic lymphocytic leukemia
title_full Proteomics insights into the pathology and prognosis of chronic lymphocytic leukemia
title_fullStr Proteomics insights into the pathology and prognosis of chronic lymphocytic leukemia
title_full_unstemmed Proteomics insights into the pathology and prognosis of chronic lymphocytic leukemia
title_short Proteomics insights into the pathology and prognosis of chronic lymphocytic leukemia
title_sort proteomics insights into the pathology and prognosis of chronic lymphocytic leukemia
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506661/
https://www.ncbi.nlm.nih.gov/pubmed/30957124
http://dx.doi.org/10.15537/smj.2019.4.23598
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