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Pre-discharge anemia as a predictor of adverse clinical outcomes in patients with acute decompensated heart failure

BACKGROUND/AIMS: The impact of the timing of anemia during hospitalization on future clinical outcomes after surviving discharge from an index heart failure (HF) has been poorly studied in patients with acute decompensated heart failure (ADHF). METHODS: A total of 384 surviving patients with acute A...

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Autores principales: Kim, Min Chul, Kim, Kye Hun, Cho, Jae Yeong, Lee, Ki Hong, Sim, Doo Sun, Yoon, Hyun Ju, Yoon, Nam Sik, Hong, Young Joon, Park, Hyung Wook, Kim, Ju Han, Ahn, Youngkeun, Jeong, Myung Ho, Cho, Jeong Gwan, Park, Jong Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Internal Medicine 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506743/
https://www.ncbi.nlm.nih.gov/pubmed/29562736
http://dx.doi.org/10.3904/kjim.2017.337
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author Kim, Min Chul
Kim, Kye Hun
Cho, Jae Yeong
Lee, Ki Hong
Sim, Doo Sun
Yoon, Hyun Ju
Yoon, Nam Sik
Hong, Young Joon
Park, Hyung Wook
Kim, Ju Han
Ahn, Youngkeun
Jeong, Myung Ho
Cho, Jeong Gwan
Park, Jong Chun
author_facet Kim, Min Chul
Kim, Kye Hun
Cho, Jae Yeong
Lee, Ki Hong
Sim, Doo Sun
Yoon, Hyun Ju
Yoon, Nam Sik
Hong, Young Joon
Park, Hyung Wook
Kim, Ju Han
Ahn, Youngkeun
Jeong, Myung Ho
Cho, Jeong Gwan
Park, Jong Chun
author_sort Kim, Min Chul
collection PubMed
description BACKGROUND/AIMS: The impact of the timing of anemia during hospitalization on future clinical outcomes after surviving discharge from an index heart failure (HF) has been poorly studied in patients with acute decompensated heart failure (ADHF). METHODS: A total of 384 surviving patients with acute ADHF were divided into two groups: an anemia group (n = 270, 199 anemia at admission and 71 pre-discharge anemia) and a no anemia group (n = 114). All-cause mortality and HF re-hospitalization were compared between groups. RESULTS: During the follow-up period (median, 528 days), death occurred in 60 patients (15.6%) and HF re-hospitalization occurred in 131 patients (34.1%). Overall anemia was associated with increased mortality (hazard ratio [HR], 1.74; 95% confidence interval [CI], 1.03 to 3.01; p = 0.039), but not HF re-hospitalization (HR, 0.92; 95% CI, 0.59 to 1.42; p = 0.707). Pre-discharge anemia was significantly associated with increased mortality (HR, 1.68; 95% CI, 1.01 to 2.82; p = 0.048), but anemia at admission did not predict increased mortality or re-hospitalization. CONCLUSIONS: Pre-discharge anemia, rather than anemia at admission, was identified as an independent predictor of mortality in patients with ADHF after surviving discharge. The results of the present study suggest that the identification and optimal management of anemia during hospitalization are important in patients with ADHF.
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spelling pubmed-65067432019-05-20 Pre-discharge anemia as a predictor of adverse clinical outcomes in patients with acute decompensated heart failure Kim, Min Chul Kim, Kye Hun Cho, Jae Yeong Lee, Ki Hong Sim, Doo Sun Yoon, Hyun Ju Yoon, Nam Sik Hong, Young Joon Park, Hyung Wook Kim, Ju Han Ahn, Youngkeun Jeong, Myung Ho Cho, Jeong Gwan Park, Jong Chun Korean J Intern Med Original Article BACKGROUND/AIMS: The impact of the timing of anemia during hospitalization on future clinical outcomes after surviving discharge from an index heart failure (HF) has been poorly studied in patients with acute decompensated heart failure (ADHF). METHODS: A total of 384 surviving patients with acute ADHF were divided into two groups: an anemia group (n = 270, 199 anemia at admission and 71 pre-discharge anemia) and a no anemia group (n = 114). All-cause mortality and HF re-hospitalization were compared between groups. RESULTS: During the follow-up period (median, 528 days), death occurred in 60 patients (15.6%) and HF re-hospitalization occurred in 131 patients (34.1%). Overall anemia was associated with increased mortality (hazard ratio [HR], 1.74; 95% confidence interval [CI], 1.03 to 3.01; p = 0.039), but not HF re-hospitalization (HR, 0.92; 95% CI, 0.59 to 1.42; p = 0.707). Pre-discharge anemia was significantly associated with increased mortality (HR, 1.68; 95% CI, 1.01 to 2.82; p = 0.048), but anemia at admission did not predict increased mortality or re-hospitalization. CONCLUSIONS: Pre-discharge anemia, rather than anemia at admission, was identified as an independent predictor of mortality in patients with ADHF after surviving discharge. The results of the present study suggest that the identification and optimal management of anemia during hospitalization are important in patients with ADHF. The Korean Association of Internal Medicine 2019-05 2018-03-23 /pmc/articles/PMC6506743/ /pubmed/29562736 http://dx.doi.org/10.3904/kjim.2017.337 Text en Copyright © 2019 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Min Chul
Kim, Kye Hun
Cho, Jae Yeong
Lee, Ki Hong
Sim, Doo Sun
Yoon, Hyun Ju
Yoon, Nam Sik
Hong, Young Joon
Park, Hyung Wook
Kim, Ju Han
Ahn, Youngkeun
Jeong, Myung Ho
Cho, Jeong Gwan
Park, Jong Chun
Pre-discharge anemia as a predictor of adverse clinical outcomes in patients with acute decompensated heart failure
title Pre-discharge anemia as a predictor of adverse clinical outcomes in patients with acute decompensated heart failure
title_full Pre-discharge anemia as a predictor of adverse clinical outcomes in patients with acute decompensated heart failure
title_fullStr Pre-discharge anemia as a predictor of adverse clinical outcomes in patients with acute decompensated heart failure
title_full_unstemmed Pre-discharge anemia as a predictor of adverse clinical outcomes in patients with acute decompensated heart failure
title_short Pre-discharge anemia as a predictor of adverse clinical outcomes in patients with acute decompensated heart failure
title_sort pre-discharge anemia as a predictor of adverse clinical outcomes in patients with acute decompensated heart failure
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506743/
https://www.ncbi.nlm.nih.gov/pubmed/29562736
http://dx.doi.org/10.3904/kjim.2017.337
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