Promiscuous Targeting of Cellular Proteins by Vpr Drives Systems-Level Proteomic Remodeling in HIV-1 Infection

HIV-1 encodes four “accessory proteins” (Vif, Vpr, Vpu, and Nef), dispensable for viral replication in vitro but essential for viral pathogenesis in vivo. Well characterized cellular targets have been associated with Vif, Vpu, and Nef, which counteract host restriction and promote viral replication....

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Detalles Bibliográficos
Autores principales: Greenwood, Edward J.D., Williamson, James C., Sienkiewicz, Agata, Naamati, Adi, Matheson, Nicholas J., Lehner, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506760/
https://www.ncbi.nlm.nih.gov/pubmed/31042482
http://dx.doi.org/10.1016/j.celrep.2019.04.025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506760/
https://www.ncbi.nlm.nih.gov/pubmed/31042482
http://dx.doi.org/10.1016/j.celrep.2019.04.025

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