Multiple myeloma with dural mater involvement

Multiple myeloma is an incurable clonal B-cell malignancy which may present with neoplastic monoclonal plasma cells in either bone or soft tissues. Central nervous system (CNS) involvement such as dural myeloma or intraparenchymal infiltration, or with diffuse leptomeningeal involvement, is uncommon...

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Autores principales: Liu, Su, Li, Xubin, Li, Yueyang, Li, Dongying, Wang, Yafei, Tian, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506830/
https://www.ncbi.nlm.nih.gov/pubmed/31118689
http://dx.doi.org/10.2147/OTT.S202662
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author Liu, Su
Li, Xubin
Li, Yueyang
Li, Dongying
Wang, Yafei
Tian, Chen
author_facet Liu, Su
Li, Xubin
Li, Yueyang
Li, Dongying
Wang, Yafei
Tian, Chen
author_sort Liu, Su
collection PubMed
description Multiple myeloma is an incurable clonal B-cell malignancy which may present with neoplastic monoclonal plasma cells in either bone or soft tissues. Central nervous system (CNS) involvement such as dural myeloma or intraparenchymal infiltration, or with diffuse leptomeningeal involvement, is uncommon. Dural involvement of myeloma without parenchymal or leptomeningeal disease is an even rarer occurrence; therefore there are no established treatment guidelines for CNS myelomatosis. Here we reported a refractory MM patient progressed to dura mater involvement after the induction therapy but showed good response to lenalidomide treatment.
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spelling pubmed-65068302019-05-22 Multiple myeloma with dural mater involvement Liu, Su Li, Xubin Li, Yueyang Li, Dongying Wang, Yafei Tian, Chen Onco Targets Ther Case Report Multiple myeloma is an incurable clonal B-cell malignancy which may present with neoplastic monoclonal plasma cells in either bone or soft tissues. Central nervous system (CNS) involvement such as dural myeloma or intraparenchymal infiltration, or with diffuse leptomeningeal involvement, is uncommon. Dural involvement of myeloma without parenchymal or leptomeningeal disease is an even rarer occurrence; therefore there are no established treatment guidelines for CNS myelomatosis. Here we reported a refractory MM patient progressed to dura mater involvement after the induction therapy but showed good response to lenalidomide treatment. Dove 2019-05-03 /pmc/articles/PMC6506830/ /pubmed/31118689 http://dx.doi.org/10.2147/OTT.S202662 Text en © 2019 Liu et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Case Report
Liu, Su
Li, Xubin
Li, Yueyang
Li, Dongying
Wang, Yafei
Tian, Chen
Multiple myeloma with dural mater involvement
title Multiple myeloma with dural mater involvement
title_full Multiple myeloma with dural mater involvement
title_fullStr Multiple myeloma with dural mater involvement
title_full_unstemmed Multiple myeloma with dural mater involvement
title_short Multiple myeloma with dural mater involvement
title_sort multiple myeloma with dural mater involvement
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506830/
https://www.ncbi.nlm.nih.gov/pubmed/31118689
http://dx.doi.org/10.2147/OTT.S202662
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