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Human lung fibroblast-to-myofibroblast transformation is not driven by an LDH5-dependent metabolic shift towards aerobic glycolysis
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a fatal respiratory disease characterized by aberrant fibroblast activation and progressive fibrotic remodelling of the lungs. Though the exact pathophysiological mechanisms of IPF remain unknown, TGF-β1 is thought to act as a main driver of the dis...
Autores principales: | Schruf, Eva, Schroeder, Victoria, Kuttruff, Christian A., Weigle, Sabine, Krell, Martin, Benz, Maryke, Bretschneider, Tom, Holweg, Alexander, Schuler, Michael, Frick, Manfred, Nicklin, Paul, Garnett, James P., Sobotta, Mirko C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6507142/ https://www.ncbi.nlm.nih.gov/pubmed/31072408 http://dx.doi.org/10.1186/s12931-019-1058-2 |
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