Human lung fibroblast-to-myofibroblast transformation is not driven by an LDH5-dependent metabolic shift towards aerobic glycolysis

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a fatal respiratory disease characterized by aberrant fibroblast activation and progressive fibrotic remodelling of the lungs. Though the exact pathophysiological mechanisms of IPF remain unknown, TGF-β1 is thought to act as a main driver of the dis...

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Detalles Bibliográficos
Autores principales: Schruf, Eva, Schroeder, Victoria, Kuttruff, Christian A., Weigle, Sabine, Krell, Martin, Benz, Maryke, Bretschneider, Tom, Holweg, Alexander, Schuler, Michael, Frick, Manfred, Nicklin, Paul, Garnett, James P., Sobotta, Mirko C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6507142/
https://www.ncbi.nlm.nih.gov/pubmed/31072408
http://dx.doi.org/10.1186/s12931-019-1058-2

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