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Speed of Retinal Vascularization in Retinopathy of Prematurity: Risk and Protective Factors
OBJECTIVE: The objective was to study the risk and protective factors involved in retinal vascular development of preterm infants with retinopathy of prematurity. METHODS: Between 2000 and 2017, 185 preterm infants were included in the protocol for retinopathy of prematurity. Risk factors associated...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6507164/ https://www.ncbi.nlm.nih.gov/pubmed/31231670 http://dx.doi.org/10.1155/2019/2721578 |
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author | Solans Pérez de Larraya, Ana Maria Ortega Molina, José María Uberos Fernández, José González Ramírez, Amanda Rocío García Serrano, José Luis |
author_facet | Solans Pérez de Larraya, Ana Maria Ortega Molina, José María Uberos Fernández, José González Ramírez, Amanda Rocío García Serrano, José Luis |
author_sort | Solans Pérez de Larraya, Ana Maria |
collection | PubMed |
description | OBJECTIVE: The objective was to study the risk and protective factors involved in retinal vascular development of preterm infants with retinopathy of prematurity. METHODS: Between 2000 and 2017, 185 preterm infants were included in the protocol for retinopathy of prematurity. Risk factors associated with speed of retinal vascularization <0.5 disc diameter/week were studied in each of them. RESULTS: The statistically significant variables related to retinal vascular development <0.5 DD/w were intubation days, degree 3 of bronchopulmonary dysplasia, weight gain at 4-6 weeks, avascular temporal area, gestational age, number of transfusions, sepsis, number of risk factors, apnea at birth, presence of ductus arteriosus, and days of continuous positive airway pressure therapy. After the multivariate logistic regression analysis, only three variables were found to be significant: intubation days (p=0.005), degree 3 of bronchopulmonary dysplasia (p=0.022), and weight gain at 4–6 weeks (p=0.031). CONCLUSION: In retinopathy of prematurity, degree 3 of bronchopulmonary dysplasia and intubation days cause delayed retinal vascular development, whereas greater postnatal weight gain favors an appropriate rate of retinal vascularization. |
format | Online Article Text |
id | pubmed-6507164 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-65071642019-06-23 Speed of Retinal Vascularization in Retinopathy of Prematurity: Risk and Protective Factors Solans Pérez de Larraya, Ana Maria Ortega Molina, José María Uberos Fernández, José González Ramírez, Amanda Rocío García Serrano, José Luis Biomed Res Int Research Article OBJECTIVE: The objective was to study the risk and protective factors involved in retinal vascular development of preterm infants with retinopathy of prematurity. METHODS: Between 2000 and 2017, 185 preterm infants were included in the protocol for retinopathy of prematurity. Risk factors associated with speed of retinal vascularization <0.5 disc diameter/week were studied in each of them. RESULTS: The statistically significant variables related to retinal vascular development <0.5 DD/w were intubation days, degree 3 of bronchopulmonary dysplasia, weight gain at 4-6 weeks, avascular temporal area, gestational age, number of transfusions, sepsis, number of risk factors, apnea at birth, presence of ductus arteriosus, and days of continuous positive airway pressure therapy. After the multivariate logistic regression analysis, only three variables were found to be significant: intubation days (p=0.005), degree 3 of bronchopulmonary dysplasia (p=0.022), and weight gain at 4–6 weeks (p=0.031). CONCLUSION: In retinopathy of prematurity, degree 3 of bronchopulmonary dysplasia and intubation days cause delayed retinal vascular development, whereas greater postnatal weight gain favors an appropriate rate of retinal vascularization. Hindawi 2019-04-24 /pmc/articles/PMC6507164/ /pubmed/31231670 http://dx.doi.org/10.1155/2019/2721578 Text en Copyright © 2019 Ana Maria Solans Pérez de Larraya et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Solans Pérez de Larraya, Ana Maria Ortega Molina, José María Uberos Fernández, José González Ramírez, Amanda Rocío García Serrano, José Luis Speed of Retinal Vascularization in Retinopathy of Prematurity: Risk and Protective Factors |
title | Speed of Retinal Vascularization in Retinopathy of Prematurity: Risk and Protective Factors |
title_full | Speed of Retinal Vascularization in Retinopathy of Prematurity: Risk and Protective Factors |
title_fullStr | Speed of Retinal Vascularization in Retinopathy of Prematurity: Risk and Protective Factors |
title_full_unstemmed | Speed of Retinal Vascularization in Retinopathy of Prematurity: Risk and Protective Factors |
title_short | Speed of Retinal Vascularization in Retinopathy of Prematurity: Risk and Protective Factors |
title_sort | speed of retinal vascularization in retinopathy of prematurity: risk and protective factors |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6507164/ https://www.ncbi.nlm.nih.gov/pubmed/31231670 http://dx.doi.org/10.1155/2019/2721578 |
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