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Speed of Retinal Vascularization in Retinopathy of Prematurity: Risk and Protective Factors

OBJECTIVE: The objective was to study the risk and protective factors involved in retinal vascular development of preterm infants with retinopathy of prematurity. METHODS: Between 2000 and 2017, 185 preterm infants were included in the protocol for retinopathy of prematurity. Risk factors associated...

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Autores principales: Solans Pérez de Larraya, Ana Maria, Ortega Molina, José María, Uberos Fernández, José, González Ramírez, Amanda Rocío, García Serrano, José Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6507164/
https://www.ncbi.nlm.nih.gov/pubmed/31231670
http://dx.doi.org/10.1155/2019/2721578
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author Solans Pérez de Larraya, Ana Maria
Ortega Molina, José María
Uberos Fernández, José
González Ramírez, Amanda Rocío
García Serrano, José Luis
author_facet Solans Pérez de Larraya, Ana Maria
Ortega Molina, José María
Uberos Fernández, José
González Ramírez, Amanda Rocío
García Serrano, José Luis
author_sort Solans Pérez de Larraya, Ana Maria
collection PubMed
description OBJECTIVE: The objective was to study the risk and protective factors involved in retinal vascular development of preterm infants with retinopathy of prematurity. METHODS: Between 2000 and 2017, 185 preterm infants were included in the protocol for retinopathy of prematurity. Risk factors associated with speed of retinal vascularization <0.5 disc diameter/week were studied in each of them. RESULTS: The statistically significant variables related to retinal vascular development <0.5 DD/w were intubation days, degree 3 of bronchopulmonary dysplasia, weight gain at 4-6 weeks, avascular temporal area, gestational age, number of transfusions, sepsis, number of risk factors, apnea at birth, presence of ductus arteriosus, and days of continuous positive airway pressure therapy. After the multivariate logistic regression analysis, only three variables were found to be significant: intubation days (p=0.005), degree 3 of bronchopulmonary dysplasia (p=0.022), and weight gain at 4–6 weeks (p=0.031). CONCLUSION: In retinopathy of prematurity, degree 3 of bronchopulmonary dysplasia and intubation days cause delayed retinal vascular development, whereas greater postnatal weight gain favors an appropriate rate of retinal vascularization.
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spelling pubmed-65071642019-06-23 Speed of Retinal Vascularization in Retinopathy of Prematurity: Risk and Protective Factors Solans Pérez de Larraya, Ana Maria Ortega Molina, José María Uberos Fernández, José González Ramírez, Amanda Rocío García Serrano, José Luis Biomed Res Int Research Article OBJECTIVE: The objective was to study the risk and protective factors involved in retinal vascular development of preterm infants with retinopathy of prematurity. METHODS: Between 2000 and 2017, 185 preterm infants were included in the protocol for retinopathy of prematurity. Risk factors associated with speed of retinal vascularization <0.5 disc diameter/week were studied in each of them. RESULTS: The statistically significant variables related to retinal vascular development <0.5 DD/w were intubation days, degree 3 of bronchopulmonary dysplasia, weight gain at 4-6 weeks, avascular temporal area, gestational age, number of transfusions, sepsis, number of risk factors, apnea at birth, presence of ductus arteriosus, and days of continuous positive airway pressure therapy. After the multivariate logistic regression analysis, only three variables were found to be significant: intubation days (p=0.005), degree 3 of bronchopulmonary dysplasia (p=0.022), and weight gain at 4–6 weeks (p=0.031). CONCLUSION: In retinopathy of prematurity, degree 3 of bronchopulmonary dysplasia and intubation days cause delayed retinal vascular development, whereas greater postnatal weight gain favors an appropriate rate of retinal vascularization. Hindawi 2019-04-24 /pmc/articles/PMC6507164/ /pubmed/31231670 http://dx.doi.org/10.1155/2019/2721578 Text en Copyright © 2019 Ana Maria Solans Pérez de Larraya et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Solans Pérez de Larraya, Ana Maria
Ortega Molina, José María
Uberos Fernández, José
González Ramírez, Amanda Rocío
García Serrano, José Luis
Speed of Retinal Vascularization in Retinopathy of Prematurity: Risk and Protective Factors
title Speed of Retinal Vascularization in Retinopathy of Prematurity: Risk and Protective Factors
title_full Speed of Retinal Vascularization in Retinopathy of Prematurity: Risk and Protective Factors
title_fullStr Speed of Retinal Vascularization in Retinopathy of Prematurity: Risk and Protective Factors
title_full_unstemmed Speed of Retinal Vascularization in Retinopathy of Prematurity: Risk and Protective Factors
title_short Speed of Retinal Vascularization in Retinopathy of Prematurity: Risk and Protective Factors
title_sort speed of retinal vascularization in retinopathy of prematurity: risk and protective factors
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6507164/
https://www.ncbi.nlm.nih.gov/pubmed/31231670
http://dx.doi.org/10.1155/2019/2721578
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