Rivaroxaban, a Direct Factor Xa Inhibitor, Ameliorates Hypertensive Renal Damage Through Inhibition of the Inflammatory Response Mediated by Protease‐Activated Receptor Pathway

BACKGROUND: An enhanced renin‐angiotensin system causes hypertensive renal damage. Factor Xa not only functions in the coagulation cascade but also activates intracellular signaling through protease‐activated receptors (PAR). We investigated the effects of rivaroxaban, a factor Xa inhibitor, on hype...

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Detalles Bibliográficos
Autores principales: Ichikawa, Hiroaki, Shimada, Michiko, Narita, Masato, Narita, Ikuyo, Kimura, Yoshihiro, Tanaka, Makoto, Osanai, Tomohiro, Okumura, Ken, Tomita, Hirofumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6507187/
https://www.ncbi.nlm.nih.gov/pubmed/30957622
http://dx.doi.org/10.1161/JAHA.119.012195

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