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Comparing the Sensitivity and Specificity of Two-Dimensional Shear Wave Elastography and Fine Needle Aspiration in Determining Malignant Thyroid Nodules
BACKGROUND: Malignancy in thyroid nodules is a common clinical problem, and epidemiological studies have shown that it is increasing. Since malignancy is a very important problem in treating patients and misdiagnosis leads to many physical and financial damages, the importance of diagnostic methods...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6507363/ https://www.ncbi.nlm.nih.gov/pubmed/31114770 http://dx.doi.org/10.4103/abr.abr_215_18 |
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author | Farghadani, Maryam Tabatabaei, Sayyid Amir Barikbin, Roozbeh Shahsanai, Armindokht Riahinezhad, Maryam Jafarpishe, Saleh |
author_facet | Farghadani, Maryam Tabatabaei, Sayyid Amir Barikbin, Roozbeh Shahsanai, Armindokht Riahinezhad, Maryam Jafarpishe, Saleh |
author_sort | Farghadani, Maryam |
collection | PubMed |
description | BACKGROUND: Malignancy in thyroid nodules is a common clinical problem, and epidemiological studies have shown that it is increasing. Since malignancy is a very important problem in treating patients and misdiagnosis leads to many physical and financial damages, the importance of diagnostic methods becomes more important. Hence, the aim of this study was to investigate the sensitivity and specificity of the two dimensional-shear wave elastography (2D-SWE) diagnostic method in comparison with fine-needle aspiration (FNA) in determining the malignant thyroid nodules. MATERIALS AND METHODS: This study is cross-sectional which was performed on 57 thyroid nodules are proven by conventional ultrasound. Afterward, 2D-SWE images were taken with the help of a superSonic ultrasound machine. Then, FNA was performed from the thyroid nodules and the specimens were evaluated in a single specialized thyroid pathology center. The results of conventional sonography and 2D-SWE were compared with histopathologic results as a gold standard method. The elasticity quantity was recorded by measuring the amount of the appropriate quantities by a recording machine and analyzed using the SPSS and MedCalc software. RESULTS: From 57 nodules studied, 50 nodules were evaluated with benign diagnosis and 7 nodules with the malignant diagnosis. Among all the parameters recorded by the machine, SWE. ratio provided the highest surface area under the curve and the highest sensitivity and specificity with 0.94, 100% and 84%, respectively, and a cut-off point of 1.7. CONCLUSION: The 2D-SWE method and the conventional ultrasound can be good references for decision making about with the thyroid nodules. |
format | Online Article Text |
id | pubmed-6507363 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-65073632019-05-21 Comparing the Sensitivity and Specificity of Two-Dimensional Shear Wave Elastography and Fine Needle Aspiration in Determining Malignant Thyroid Nodules Farghadani, Maryam Tabatabaei, Sayyid Amir Barikbin, Roozbeh Shahsanai, Armindokht Riahinezhad, Maryam Jafarpishe, Saleh Adv Biomed Res Original Article BACKGROUND: Malignancy in thyroid nodules is a common clinical problem, and epidemiological studies have shown that it is increasing. Since malignancy is a very important problem in treating patients and misdiagnosis leads to many physical and financial damages, the importance of diagnostic methods becomes more important. Hence, the aim of this study was to investigate the sensitivity and specificity of the two dimensional-shear wave elastography (2D-SWE) diagnostic method in comparison with fine-needle aspiration (FNA) in determining the malignant thyroid nodules. MATERIALS AND METHODS: This study is cross-sectional which was performed on 57 thyroid nodules are proven by conventional ultrasound. Afterward, 2D-SWE images were taken with the help of a superSonic ultrasound machine. Then, FNA was performed from the thyroid nodules and the specimens were evaluated in a single specialized thyroid pathology center. The results of conventional sonography and 2D-SWE were compared with histopathologic results as a gold standard method. The elasticity quantity was recorded by measuring the amount of the appropriate quantities by a recording machine and analyzed using the SPSS and MedCalc software. RESULTS: From 57 nodules studied, 50 nodules were evaluated with benign diagnosis and 7 nodules with the malignant diagnosis. Among all the parameters recorded by the machine, SWE. ratio provided the highest surface area under the curve and the highest sensitivity and specificity with 0.94, 100% and 84%, respectively, and a cut-off point of 1.7. CONCLUSION: The 2D-SWE method and the conventional ultrasound can be good references for decision making about with the thyroid nodules. Wolters Kluwer - Medknow 2019-04-26 /pmc/articles/PMC6507363/ /pubmed/31114770 http://dx.doi.org/10.4103/abr.abr_215_18 Text en Copyright: © 2019 Advanced Biomedical Research http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Farghadani, Maryam Tabatabaei, Sayyid Amir Barikbin, Roozbeh Shahsanai, Armindokht Riahinezhad, Maryam Jafarpishe, Saleh Comparing the Sensitivity and Specificity of Two-Dimensional Shear Wave Elastography and Fine Needle Aspiration in Determining Malignant Thyroid Nodules |
title | Comparing the Sensitivity and Specificity of Two-Dimensional Shear Wave Elastography and Fine Needle Aspiration in Determining Malignant Thyroid Nodules |
title_full | Comparing the Sensitivity and Specificity of Two-Dimensional Shear Wave Elastography and Fine Needle Aspiration in Determining Malignant Thyroid Nodules |
title_fullStr | Comparing the Sensitivity and Specificity of Two-Dimensional Shear Wave Elastography and Fine Needle Aspiration in Determining Malignant Thyroid Nodules |
title_full_unstemmed | Comparing the Sensitivity and Specificity of Two-Dimensional Shear Wave Elastography and Fine Needle Aspiration in Determining Malignant Thyroid Nodules |
title_short | Comparing the Sensitivity and Specificity of Two-Dimensional Shear Wave Elastography and Fine Needle Aspiration in Determining Malignant Thyroid Nodules |
title_sort | comparing the sensitivity and specificity of two-dimensional shear wave elastography and fine needle aspiration in determining malignant thyroid nodules |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6507363/ https://www.ncbi.nlm.nih.gov/pubmed/31114770 http://dx.doi.org/10.4103/abr.abr_215_18 |
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