lncRNA-NEF is downregulated in osteosarcoma and inhibits cancer cell migration and invasion by downregulating miRNA-21

Long non-coding RNA (lncRNA)-NEF inhibits cancer metastasis in hepatocellular carcinoma; however, its role in other malignancies is unknown. The present study revealed that plasma lncRNA-NEF was downregulated, while miRNA-21 was upregulated in patients with osteosarcoma compared with healthy control...

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Autores principales: Yang, Qinglei, Yu, Hongying, Yin, Qingshui, Hu, Xiaoming, Zhang, Chengcheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6507433/
https://www.ncbi.nlm.nih.gov/pubmed/31186758
http://dx.doi.org/10.3892/ol.2019.10276
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author Yang, Qinglei
Yu, Hongying
Yin, Qingshui
Hu, Xiaoming
Zhang, Chengcheng
author_facet Yang, Qinglei
Yu, Hongying
Yin, Qingshui
Hu, Xiaoming
Zhang, Chengcheng
author_sort Yang, Qinglei
collection PubMed
description Long non-coding RNA (lncRNA)-NEF inhibits cancer metastasis in hepatocellular carcinoma; however, its role in other malignancies is unknown. The present study revealed that plasma lncRNA-NEF was downregulated, while miRNA-21 was upregulated in patients with osteosarcoma compared with healthy controls. Plasma lncRNA-NEF and miRNA-21 were negatively correlated in patients with osteosarcoma and healthy controls. Downregulation of lncRNA-NEF and upregulation of miRNA-21 distinguished patients with osteosarcoma from healthy controls. lncRNA-NEF overexpression mediated the inhibition of miRNA-21 expression in osteosarcoma cell lines, while miRNA-21 overexpression did not significantly affect the expression of lncRNA-NEF. lncRNA-NEF overexpression inhibited, while miRNA-21 overexpression promoted, migration and invasion of osteosarcoma cell lines in vitro. miRNA-21 overexpression partially compensated the inhibitory effects of lncRNA-NEF overexpression on osteosarcoma cell migration and invasion. Therefore, lncRNA-NEF may inhibit cancer cell migration and invasion in osteosarcoma by downregulating miRNA-21.
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spelling pubmed-65074332019-06-11 lncRNA-NEF is downregulated in osteosarcoma and inhibits cancer cell migration and invasion by downregulating miRNA-21 Yang, Qinglei Yu, Hongying Yin, Qingshui Hu, Xiaoming Zhang, Chengcheng Oncol Lett Articles Long non-coding RNA (lncRNA)-NEF inhibits cancer metastasis in hepatocellular carcinoma; however, its role in other malignancies is unknown. The present study revealed that plasma lncRNA-NEF was downregulated, while miRNA-21 was upregulated in patients with osteosarcoma compared with healthy controls. Plasma lncRNA-NEF and miRNA-21 were negatively correlated in patients with osteosarcoma and healthy controls. Downregulation of lncRNA-NEF and upregulation of miRNA-21 distinguished patients with osteosarcoma from healthy controls. lncRNA-NEF overexpression mediated the inhibition of miRNA-21 expression in osteosarcoma cell lines, while miRNA-21 overexpression did not significantly affect the expression of lncRNA-NEF. lncRNA-NEF overexpression inhibited, while miRNA-21 overexpression promoted, migration and invasion of osteosarcoma cell lines in vitro. miRNA-21 overexpression partially compensated the inhibitory effects of lncRNA-NEF overexpression on osteosarcoma cell migration and invasion. Therefore, lncRNA-NEF may inhibit cancer cell migration and invasion in osteosarcoma by downregulating miRNA-21. D.A. Spandidos 2019-06 2019-04-18 /pmc/articles/PMC6507433/ /pubmed/31186758 http://dx.doi.org/10.3892/ol.2019.10276 Text en Copyright: © Yang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Yang, Qinglei
Yu, Hongying
Yin, Qingshui
Hu, Xiaoming
Zhang, Chengcheng
lncRNA-NEF is downregulated in osteosarcoma and inhibits cancer cell migration and invasion by downregulating miRNA-21
title lncRNA-NEF is downregulated in osteosarcoma and inhibits cancer cell migration and invasion by downregulating miRNA-21
title_full lncRNA-NEF is downregulated in osteosarcoma and inhibits cancer cell migration and invasion by downregulating miRNA-21
title_fullStr lncRNA-NEF is downregulated in osteosarcoma and inhibits cancer cell migration and invasion by downregulating miRNA-21
title_full_unstemmed lncRNA-NEF is downregulated in osteosarcoma and inhibits cancer cell migration and invasion by downregulating miRNA-21
title_short lncRNA-NEF is downregulated in osteosarcoma and inhibits cancer cell migration and invasion by downregulating miRNA-21
title_sort lncrna-nef is downregulated in osteosarcoma and inhibits cancer cell migration and invasion by downregulating mirna-21
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6507433/
https://www.ncbi.nlm.nih.gov/pubmed/31186758
http://dx.doi.org/10.3892/ol.2019.10276
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