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High degree of fluoroquinolone resistance among pulmonary tuberculosis patients in New Delhi, India
BACKGROUND & OBJECTIVES: The fluoroquinolones (FQs) group of antibiotics is the backbone drugs for the management of drug-resistant tuberculosis (TB). In routine clinical practice, drug susceptibility testing (DST) for FQs is not performed, and the patients are empirically treated. A limited inf...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6507539/ https://www.ncbi.nlm.nih.gov/pubmed/31115377 http://dx.doi.org/10.4103/ijmr.IJMR_1220_17 |
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author | Sharma, Rohini Sharma, Surendra Kumar Singh, Binit Kumar Mittal, Abhenil Kumar, Prahlad |
author_facet | Sharma, Rohini Sharma, Surendra Kumar Singh, Binit Kumar Mittal, Abhenil Kumar, Prahlad |
author_sort | Sharma, Rohini |
collection | PubMed |
description | BACKGROUND & OBJECTIVES: The fluoroquinolones (FQs) group of antibiotics is the backbone drugs for the management of drug-resistant tuberculosis (TB). In routine clinical practice, drug susceptibility testing (DST) for FQs is not performed, and the patients are empirically treated. A limited information exists regarding FQs resistance among pulmonary TB cases. The present study was conducted to determine the FQs resistance among drug sensitive and drug-resistant pulmonary TB patients in a tertiary care centre in north India. METHODS: A total of 1619 sputum/smear-positive specimens of pulmonary TB patients were subjected to DST for first-line drugs (FLDs) and second-line drugs. In addition, FQs DST was also performed using automated Mycobacterial Growth Indicator Tube-960 liquid culture technique. The immuno-chromatographic assay was performed to distinguish Mycobacterium tuberculosis complex (MTBC) from non-MTBC. RESULTS: Mycobacterium tuberculosis (Mtb) was isolated in 1499 sputum specimens; 1099 culture specimens were sensitive to FLDs, 249 grew as multidrug-resistant (MDR) Mtb and the remaining 151 isolates revealed any drug resistance to FLDs. While FQs monoresistance among the FLD sensitive isolates was 3.1 per cent (35/1099), 27.3 per cent (68/249) among MDR Mtb isolates had additional FQs resistance. INTERPRETATION & CONCLUSIONS: FQs resistance among drug sensitive and MDR Mtb isolates was high in Delhi, India. Based on these findings, it is recommended that the DST for FQs should be routinely performed to avoid further amplification of drug resistance. |
format | Online Article Text |
id | pubmed-6507539 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-65075392019-05-21 High degree of fluoroquinolone resistance among pulmonary tuberculosis patients in New Delhi, India Sharma, Rohini Sharma, Surendra Kumar Singh, Binit Kumar Mittal, Abhenil Kumar, Prahlad Indian J Med Res Original Article BACKGROUND & OBJECTIVES: The fluoroquinolones (FQs) group of antibiotics is the backbone drugs for the management of drug-resistant tuberculosis (TB). In routine clinical practice, drug susceptibility testing (DST) for FQs is not performed, and the patients are empirically treated. A limited information exists regarding FQs resistance among pulmonary TB cases. The present study was conducted to determine the FQs resistance among drug sensitive and drug-resistant pulmonary TB patients in a tertiary care centre in north India. METHODS: A total of 1619 sputum/smear-positive specimens of pulmonary TB patients were subjected to DST for first-line drugs (FLDs) and second-line drugs. In addition, FQs DST was also performed using automated Mycobacterial Growth Indicator Tube-960 liquid culture technique. The immuno-chromatographic assay was performed to distinguish Mycobacterium tuberculosis complex (MTBC) from non-MTBC. RESULTS: Mycobacterium tuberculosis (Mtb) was isolated in 1499 sputum specimens; 1099 culture specimens were sensitive to FLDs, 249 grew as multidrug-resistant (MDR) Mtb and the remaining 151 isolates revealed any drug resistance to FLDs. While FQs monoresistance among the FLD sensitive isolates was 3.1 per cent (35/1099), 27.3 per cent (68/249) among MDR Mtb isolates had additional FQs resistance. INTERPRETATION & CONCLUSIONS: FQs resistance among drug sensitive and MDR Mtb isolates was high in Delhi, India. Based on these findings, it is recommended that the DST for FQs should be routinely performed to avoid further amplification of drug resistance. Medknow Publications & Media Pvt Ltd 2019-01 /pmc/articles/PMC6507539/ /pubmed/31115377 http://dx.doi.org/10.4103/ijmr.IJMR_1220_17 Text en Copyright: © 2019 Indian Journal of Medical Research http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Sharma, Rohini Sharma, Surendra Kumar Singh, Binit Kumar Mittal, Abhenil Kumar, Prahlad High degree of fluoroquinolone resistance among pulmonary tuberculosis patients in New Delhi, India |
title | High degree of fluoroquinolone resistance among pulmonary tuberculosis patients in New Delhi, India |
title_full | High degree of fluoroquinolone resistance among pulmonary tuberculosis patients in New Delhi, India |
title_fullStr | High degree of fluoroquinolone resistance among pulmonary tuberculosis patients in New Delhi, India |
title_full_unstemmed | High degree of fluoroquinolone resistance among pulmonary tuberculosis patients in New Delhi, India |
title_short | High degree of fluoroquinolone resistance among pulmonary tuberculosis patients in New Delhi, India |
title_sort | high degree of fluoroquinolone resistance among pulmonary tuberculosis patients in new delhi, india |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6507539/ https://www.ncbi.nlm.nih.gov/pubmed/31115377 http://dx.doi.org/10.4103/ijmr.IJMR_1220_17 |
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