Defect of SIRT1-FoxO3a axis is associated with the production of reactive oxygen species during protein kinase CK2 downregulation-mediated cellular senescence and nematode aging

We investigated whether SIRT1 is associated with reactive oxygen species (ROS) accumulation during CK2 downregulation-mediated senescence. SIRT1 overexpression suppressed ROS accumulation, reduced transcription of FoxO3a target genes, and nuclear export and acetylation of FoxO3a, which were induced...

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Detalles Bibliográficos
Autores principales: Ham, Hye-Jun, Park, Jeong-Woo, Bae, Young-Seuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6507845/
https://www.ncbi.nlm.nih.gov/pubmed/30103847
http://dx.doi.org/10.5483/BMBRep.2019.52.4.156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6507845/
https://www.ncbi.nlm.nih.gov/pubmed/30103847
http://dx.doi.org/10.5483/BMBRep.2019.52.4.156

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