P-cadherin mutations are associated with high basal Wnt activity and stemness in canine mammary tumor cell lines

Purpose: To find underlying mutations causing highly-activated Wnt activity in mammary tumor cell lines associated with rounded morphology indicative of stemness/EMT. Methods: Stemness of high Wnt cell lines was confirmed using qPCR on selected genes and microRNA profiling, followed by whole-exome s...

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Detalles Bibliográficos
Autores principales: Timmermans-Sprang, Elpetra, Collin, Rob, Henkes, Arjen, Philipsen, Meike, Mol, Jan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6508207/
https://www.ncbi.nlm.nih.gov/pubmed/31105876
http://dx.doi.org/10.18632/oncotarget.26873

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6508207/
https://www.ncbi.nlm.nih.gov/pubmed/31105876
http://dx.doi.org/10.18632/oncotarget.26873

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