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P-cadherin mutations are associated with high basal Wnt activity and stemness in canine mammary tumor cell lines

Purpose: To find underlying mutations causing highly-activated Wnt activity in mammary tumor cell lines associated with rounded morphology indicative of stemness/EMT. Methods: Stemness of high Wnt cell lines was confirmed using qPCR on selected genes and microRNA profiling, followed by whole-exome s...

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Detalles Bibliográficos
Autores principales:	Timmermans-Sprang, Elpetra, Collin, Rob, Henkes, Arjen, Philipsen, Meike, Mol, Jan A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6508207/ https://www.ncbi.nlm.nih.gov/pubmed/31105876 http://dx.doi.org/10.18632/oncotarget.26873

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