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Serum Bovine Immunoglobulins Improve Inflammation and Gut Barrier Function in Persons with HIV and Enteropathy on Suppressive ART

BACKGROUND: Systemic inflammation persists in chronic HIV infection and is associated with increased rates of non-AIDS events such as cardiovascular and liver disease. Increased gut permeability and systemic exposure to microbial products are key drivers of this inflammation. Serum-derived bovine im...

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Autores principales: Utay, Netanya S., Somasunderam, Anoma, Hinkle, John E., Petschow, Bryon W., Detzel, Christopher J., Somsouk, Ma, Fichtenbaum, Carl J., Weaver, Eric M., Shaw, Audrey L., Asmuth, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pathogens and Immunity 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6508431/
https://www.ncbi.nlm.nih.gov/pubmed/31139758
http://dx.doi.org/10.20411/pai.v4i1.276
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author Utay, Netanya S.
Somasunderam, Anoma
Hinkle, John E.
Petschow, Bryon W.
Detzel, Christopher J.
Somsouk, Ma
Fichtenbaum, Carl J.
Weaver, Eric M.
Shaw, Audrey L.
Asmuth, David M.
author_facet Utay, Netanya S.
Somasunderam, Anoma
Hinkle, John E.
Petschow, Bryon W.
Detzel, Christopher J.
Somsouk, Ma
Fichtenbaum, Carl J.
Weaver, Eric M.
Shaw, Audrey L.
Asmuth, David M.
author_sort Utay, Netanya S.
collection PubMed
description BACKGROUND: Systemic inflammation persists in chronic HIV infection and is associated with increased rates of non-AIDS events such as cardiovascular and liver disease. Increased gut permeability and systemic exposure to microbial products are key drivers of this inflammation. Serum-derived bovine immunoglobulin/protein isolate (SBI) supports gut healing in other conditions such as inflammatory bowel disease. METHODS: In this randomized, double-blind study, participants receiving suppressive antiretroviral therapy (ART) with chronic diarrhea received placebo or SBI at 2.5 g BID or 5 g BID for 4 weeks, followed by a 20-week placebo-free extension phase with SBI at either 2.5 or 5 g BID. Intestinal fatty acid binding protein (I-FABP), zonulin, flagellin, lipopolysaccharide (LPS) and LPS-binding protein, and inflammatory markers were measured by ELISA or multiplex assays. Non-parametric tests were used for analysis. RESULTS: One hundred three participants completed the study. By week 24 SBI significantly decreased circulating levels of I-FABP (-0.35 ng/μL, P=0.002) and zonulin (-4.90 ng/μL, P=0.003), suggesting improvement in gut damage, and interleukin-6 (IL-6) (-0.40 pg/μL, P=0.002), reflecting improvement in systemic inflammation. In participants with the lowest quartile of CD4+ T-cell counts at baseline (189-418 cells/μL), CD4+ T-cell counts increased significantly (26 cells/μL; P=0.002). CONCLUSIONS: Oral SBI may decrease inflammation and warrants further exploration as a potential strategy to improve gut integrity and decrease systemic inflammation among persons receiving prolonged suppressive ART.
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spelling pubmed-65084312019-05-28 Serum Bovine Immunoglobulins Improve Inflammation and Gut Barrier Function in Persons with HIV and Enteropathy on Suppressive ART Utay, Netanya S. Somasunderam, Anoma Hinkle, John E. Petschow, Bryon W. Detzel, Christopher J. Somsouk, Ma Fichtenbaum, Carl J. Weaver, Eric M. Shaw, Audrey L. Asmuth, David M. Pathog Immun Research Article BACKGROUND: Systemic inflammation persists in chronic HIV infection and is associated with increased rates of non-AIDS events such as cardiovascular and liver disease. Increased gut permeability and systemic exposure to microbial products are key drivers of this inflammation. Serum-derived bovine immunoglobulin/protein isolate (SBI) supports gut healing in other conditions such as inflammatory bowel disease. METHODS: In this randomized, double-blind study, participants receiving suppressive antiretroviral therapy (ART) with chronic diarrhea received placebo or SBI at 2.5 g BID or 5 g BID for 4 weeks, followed by a 20-week placebo-free extension phase with SBI at either 2.5 or 5 g BID. Intestinal fatty acid binding protein (I-FABP), zonulin, flagellin, lipopolysaccharide (LPS) and LPS-binding protein, and inflammatory markers were measured by ELISA or multiplex assays. Non-parametric tests were used for analysis. RESULTS: One hundred three participants completed the study. By week 24 SBI significantly decreased circulating levels of I-FABP (-0.35 ng/μL, P=0.002) and zonulin (-4.90 ng/μL, P=0.003), suggesting improvement in gut damage, and interleukin-6 (IL-6) (-0.40 pg/μL, P=0.002), reflecting improvement in systemic inflammation. In participants with the lowest quartile of CD4+ T-cell counts at baseline (189-418 cells/μL), CD4+ T-cell counts increased significantly (26 cells/μL; P=0.002). CONCLUSIONS: Oral SBI may decrease inflammation and warrants further exploration as a potential strategy to improve gut integrity and decrease systemic inflammation among persons receiving prolonged suppressive ART. Pathogens and Immunity 2019-05-03 /pmc/articles/PMC6508431/ /pubmed/31139758 http://dx.doi.org/10.20411/pai.v4i1.276 Text en © Pathogens and Immunity 2019 This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Research Article
Utay, Netanya S.
Somasunderam, Anoma
Hinkle, John E.
Petschow, Bryon W.
Detzel, Christopher J.
Somsouk, Ma
Fichtenbaum, Carl J.
Weaver, Eric M.
Shaw, Audrey L.
Asmuth, David M.
Serum Bovine Immunoglobulins Improve Inflammation and Gut Barrier Function in Persons with HIV and Enteropathy on Suppressive ART
title Serum Bovine Immunoglobulins Improve Inflammation and Gut Barrier Function in Persons with HIV and Enteropathy on Suppressive ART
title_full Serum Bovine Immunoglobulins Improve Inflammation and Gut Barrier Function in Persons with HIV and Enteropathy on Suppressive ART
title_fullStr Serum Bovine Immunoglobulins Improve Inflammation and Gut Barrier Function in Persons with HIV and Enteropathy on Suppressive ART
title_full_unstemmed Serum Bovine Immunoglobulins Improve Inflammation and Gut Barrier Function in Persons with HIV and Enteropathy on Suppressive ART
title_short Serum Bovine Immunoglobulins Improve Inflammation and Gut Barrier Function in Persons with HIV and Enteropathy on Suppressive ART
title_sort serum bovine immunoglobulins improve inflammation and gut barrier function in persons with hiv and enteropathy on suppressive art
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6508431/
https://www.ncbi.nlm.nih.gov/pubmed/31139758
http://dx.doi.org/10.20411/pai.v4i1.276
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