Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer’s disease mouse models

Cerebral blood flow (CBF) reductions in Alzheimer’s disease (AD) patients and related mouse models have been recognized for decades, but the underlying mechanisms and resulting consequences on AD pathogenesis remain poorly understood. In APP/PS1 and 5xFAD mice we found that an increased number of co...

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Detalles Bibliográficos
Autores principales: Cruz Hernández, Jean C., Bracko, Oliver, Kersbergen, Calvin J., Muse, Victorine, Haft-Javaherian, Mohammad, Berg, Maxime, Park, Laibaik, Vinarcsik, Lindsay K., Ivasyk, Iryna, Rivera, Daniel A., Kang, Yiming, Cortes-Canteli, Marta, Peyrounette, Myriam, Doyeux, Vincent, Smith, Amy, Zhou, Joan, Otte, Gabriel, Beverly, Jeffrey D., Davenport, Elizabeth, Davit, Yohan, Lin, Charles P., Strickland, Sidney, Iadecola, Costantino, Lorthois, Sylvie, Nishimura, Nozomi, Schaffer, Chris B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6508667/
https://www.ncbi.nlm.nih.gov/pubmed/30742116
http://dx.doi.org/10.1038/s41593-018-0329-4

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