Identification of druggable small molecule antagonists of the Plasmodium falciparum hexose transporter PfHT and assessment of ligand access to the glucose permeation pathway via FLAG-mediated protein engineering

Although the Plasmodium falciparum hexose transporter PfHT has emerged as a promising target for anti-malarial therapy, previously identified small-molecule inhibitors have lacked promising drug-like structural features necessary for development as clinical therapeutics. Taking advantage of emerging...

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Detalles Bibliográficos
Autores principales: Heitmeier, Monique R., Hresko, Richard C., Edwards, Rachel L., Prinsen, Michael J., Ilagan, Ma Xenia G., Odom John, Audrey R., Hruz, Paul W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6508677/
https://www.ncbi.nlm.nih.gov/pubmed/31071153
http://dx.doi.org/10.1371/journal.pone.0216457

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