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Complement Component C3 Binds to the A3 Domain of von Willebrand Factor

von Willebrand factor (VWF) is a multimeric protein composed of monomeric subunits (∼280 kD) linked by disulfide bonds. During hemostasis and thrombosis, ultralarge (UL) VWF (ULVWF) multimers initiate platelet adhesion. In vitro, human C3 binds to ULVWF multimeric strings secreted by and anchored to...

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Detalles Bibliográficos
Autores principales:	Nolasco, Jennifer G., Nolasco, Leticia H., Da, Qi, Cirlos, Sonya, Ruggeri, Zaverio M., Moake, Joel L., Cruz, Miguel A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Georg Thieme Verlag KG 2018
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6508891/ https://www.ncbi.nlm.nih.gov/pubmed/31080944 http://dx.doi.org/10.1055/s-0038-1672189

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