A high-throughput screen of pharmacologically active compounds for inhibitors of UHRF1 reveals epigenetic activity of anthracycline derivative chemotherapeutic drugs

DNA methylation can mediate epigenetic silencing of tumor suppressor and cancer protective genes. The protein ubiquitin-like containing PHD and ring finger domains 1 (UHRF1) is an essential component in cells for DNA methylation maintenance. The SET- and RING-associated (SRA) domain of UHRF1 can bin...

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Detalles Bibliográficos
Autores principales: Giovinazzo, Hugh, Walker, David, Wyhs, Nicolas, Liu, Jianyong, Esopi, David M., Vaghasia, Ajay M., Jain, Yash, Bhamidipati, Akshay, Zhou, Jianya, Nelson, William G., Yegnasubramanian, Srinivasan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6508961/
https://www.ncbi.nlm.nih.gov/pubmed/31105884
http://dx.doi.org/10.18632/oncotarget.26889

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