A Signature of Circulating Inflammatory Proteins and Development of End Stage Renal Disease in Diabetes

Chronic inflammation is postulated to be involved in development of end stage renal disease (ESRD) in diabetes, but which specific circulating inflammatory proteins contribute to this risk remains unknown. To study this we examined 194 circulating inflammatory proteins in subjects from three indepen...

Descripción completa

Detalles Bibliográficos
Autores principales: Niewczas, Monika A., Pavkov, Meda E., Skupien, Jan, Smiles, Adam, Dom, Zaipul I. Md., Wilson, Jonathan M., Park, Jihwan, Nair, Viji, Schlafly, Andrew, Saulnier, Pierre-Jean, Satake, Eiichiro, Simeone, Christopher A., Shah, Hetal, Qiu, Chengxiang, Looker, Helen C, Fiorina, Paolo, Ware, Carl F., Sun, Jennifer K., Doria, Alessandro, Kretzler, Matthias, Susztak, Katalin, Duffin, Kevin L., Nelson, Robert G., Krolewski, Andrzej S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6508971/
https://www.ncbi.nlm.nih.gov/pubmed/31011203
http://dx.doi.org/10.1038/s41591-019-0415-5
_version_ 1783417163652005888
author Niewczas, Monika A.
Pavkov, Meda E.
Skupien, Jan
Smiles, Adam
Dom, Zaipul I. Md.
Wilson, Jonathan M.
Park, Jihwan
Nair, Viji
Schlafly, Andrew
Saulnier, Pierre-Jean
Satake, Eiichiro
Simeone, Christopher A.
Shah, Hetal
Qiu, Chengxiang
Looker, Helen C
Fiorina, Paolo
Ware, Carl F.
Sun, Jennifer K.
Doria, Alessandro
Kretzler, Matthias
Susztak, Katalin
Duffin, Kevin L.
Nelson, Robert G.
Krolewski, Andrzej S.
author_facet Niewczas, Monika A.
Pavkov, Meda E.
Skupien, Jan
Smiles, Adam
Dom, Zaipul I. Md.
Wilson, Jonathan M.
Park, Jihwan
Nair, Viji
Schlafly, Andrew
Saulnier, Pierre-Jean
Satake, Eiichiro
Simeone, Christopher A.
Shah, Hetal
Qiu, Chengxiang
Looker, Helen C
Fiorina, Paolo
Ware, Carl F.
Sun, Jennifer K.
Doria, Alessandro
Kretzler, Matthias
Susztak, Katalin
Duffin, Kevin L.
Nelson, Robert G.
Krolewski, Andrzej S.
author_sort Niewczas, Monika A.
collection PubMed
description Chronic inflammation is postulated to be involved in development of end stage renal disease (ESRD) in diabetes, but which specific circulating inflammatory proteins contribute to this risk remains unknown. To study this we examined 194 circulating inflammatory proteins in subjects from three independent cohorts with Type 1 and Type 2 diabetes. In each cohort we identified an extremely robust Kidney Risk Inflammatory Signature (KRIS) consisting of 17 novel proteins enriched for TNF Receptor Superfamily members that was associated with a 10-year risk of ESRD. All these proteins had a systemic, non-kidney source. Our prospective study findings provide strong evidence that KRIS proteins contribute to the inflammatory process underlying ESRD development in both types of diabetes. These proteins may be used as new therapeutic targets, new prognostic tests for high risk of ESRD and as surrogate outcome measures where changes in KRIS levels during intervention can reflect the tested therapy’s effectiveness.
format Online
Article
Text
id pubmed-6508971
institution National Center for Biotechnology Information
language English
publishDate 2019
record_format MEDLINE/PubMed
spelling pubmed-65089712019-10-22 A Signature of Circulating Inflammatory Proteins and Development of End Stage Renal Disease in Diabetes Niewczas, Monika A. Pavkov, Meda E. Skupien, Jan Smiles, Adam Dom, Zaipul I. Md. Wilson, Jonathan M. Park, Jihwan Nair, Viji Schlafly, Andrew Saulnier, Pierre-Jean Satake, Eiichiro Simeone, Christopher A. Shah, Hetal Qiu, Chengxiang Looker, Helen C Fiorina, Paolo Ware, Carl F. Sun, Jennifer K. Doria, Alessandro Kretzler, Matthias Susztak, Katalin Duffin, Kevin L. Nelson, Robert G. Krolewski, Andrzej S. Nat Med Article Chronic inflammation is postulated to be involved in development of end stage renal disease (ESRD) in diabetes, but which specific circulating inflammatory proteins contribute to this risk remains unknown. To study this we examined 194 circulating inflammatory proteins in subjects from three independent cohorts with Type 1 and Type 2 diabetes. In each cohort we identified an extremely robust Kidney Risk Inflammatory Signature (KRIS) consisting of 17 novel proteins enriched for TNF Receptor Superfamily members that was associated with a 10-year risk of ESRD. All these proteins had a systemic, non-kidney source. Our prospective study findings provide strong evidence that KRIS proteins contribute to the inflammatory process underlying ESRD development in both types of diabetes. These proteins may be used as new therapeutic targets, new prognostic tests for high risk of ESRD and as surrogate outcome measures where changes in KRIS levels during intervention can reflect the tested therapy’s effectiveness. 2019-04-22 2019-05 /pmc/articles/PMC6508971/ /pubmed/31011203 http://dx.doi.org/10.1038/s41591-019-0415-5 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Niewczas, Monika A.
Pavkov, Meda E.
Skupien, Jan
Smiles, Adam
Dom, Zaipul I. Md.
Wilson, Jonathan M.
Park, Jihwan
Nair, Viji
Schlafly, Andrew
Saulnier, Pierre-Jean
Satake, Eiichiro
Simeone, Christopher A.
Shah, Hetal
Qiu, Chengxiang
Looker, Helen C
Fiorina, Paolo
Ware, Carl F.
Sun, Jennifer K.
Doria, Alessandro
Kretzler, Matthias
Susztak, Katalin
Duffin, Kevin L.
Nelson, Robert G.
Krolewski, Andrzej S.
A Signature of Circulating Inflammatory Proteins and Development of End Stage Renal Disease in Diabetes
title A Signature of Circulating Inflammatory Proteins and Development of End Stage Renal Disease in Diabetes
title_full A Signature of Circulating Inflammatory Proteins and Development of End Stage Renal Disease in Diabetes
title_fullStr A Signature of Circulating Inflammatory Proteins and Development of End Stage Renal Disease in Diabetes
title_full_unstemmed A Signature of Circulating Inflammatory Proteins and Development of End Stage Renal Disease in Diabetes
title_short A Signature of Circulating Inflammatory Proteins and Development of End Stage Renal Disease in Diabetes
title_sort signature of circulating inflammatory proteins and development of end stage renal disease in diabetes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6508971/
https://www.ncbi.nlm.nih.gov/pubmed/31011203
http://dx.doi.org/10.1038/s41591-019-0415-5
work_keys_str_mv AT niewczasmonikaa asignatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT pavkovmedae asignatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT skupienjan asignatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT smilesadam asignatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT domzaipulimd asignatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT wilsonjonathanm asignatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT parkjihwan asignatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT nairviji asignatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT schlaflyandrew asignatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT saulnierpierrejean asignatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT satakeeiichiro asignatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT simeonechristophera asignatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT shahhetal asignatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT qiuchengxiang asignatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT lookerhelenc asignatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT fiorinapaolo asignatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT warecarlf asignatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT sunjenniferk asignatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT doriaalessandro asignatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT kretzlermatthias asignatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT susztakkatalin asignatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT duffinkevinl asignatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT nelsonrobertg asignatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT krolewskiandrzejs asignatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT niewczasmonikaa signatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT pavkovmedae signatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT skupienjan signatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT smilesadam signatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT domzaipulimd signatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT wilsonjonathanm signatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT parkjihwan signatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT nairviji signatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT schlaflyandrew signatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT saulnierpierrejean signatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT satakeeiichiro signatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT simeonechristophera signatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT shahhetal signatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT qiuchengxiang signatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT lookerhelenc signatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT fiorinapaolo signatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT warecarlf signatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT sunjenniferk signatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT doriaalessandro signatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT kretzlermatthias signatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT susztakkatalin signatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT duffinkevinl signatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT nelsonrobertg signatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes
AT krolewskiandrzejs signatureofcirculatinginflammatoryproteinsanddevelopmentofendstagerenaldiseaseindiabetes

Ejemplares similares